{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T01:51:16Z","timestamp":1782093076731,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glands of the uterus are essential for the establishment of pregnancy in mice and their products regulate embryo implantation and stromal cell decidualization critical for pregnancy establishment. Forkhead box A2 (FOXA2) is expressed specifically in the glands and a critical regulator of their differentiation, development and function. Progesterone and FOXA2 regulate members of a serine proteinase gene family (<jats:italic>Prss28<\/jats:italic> and <jats:italic>Prss29)<\/jats:italic>. Here, CRISPR\u2010Cas9 genome\u2010editing was used to create mice with a heterozygous or homozygous deletion of <jats:italic>Prss28<\/jats:italic> or\/and <jats:italic>Prss29<\/jats:italic> to determine their biological roles in uterine function. Female mice lacking <jats:italic>Prss28<\/jats:italic> and <jats:italic>Prss29<\/jats:italic> or both developed normally and were fertile without alterations in uterine histoarchitecture, uterine gland number, or and gene expression. Thus, Prss28 and Prss29 are dispensable for female fertility and do not impact endometrial gland development or uterine function mice.<\/jats:p>","DOI":"10.1002\/mrd.23473","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T07:43:47Z","timestamp":1620719027000},"page":"482-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Generation and analysis of <i>Prss28<\/i> and <i>Prss29<\/i> deficient mice using CRISPR\u2010Cas9 genome\u2010editing"],"prefix":"10.1002","volume":"88","author":[{"given":"Pramod","family":"Dhakal","sequence":"first","affiliation":[{"name":"Division of Animal Sciences, Gynecology, and Women's Health University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-766X","authenticated-orcid":false,"given":"Thomas 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