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Here, we review current and emerging therapeutic and experimental options for endometrial regeneration with a focus on animal models used to study solutions for Asherman's syndrome and endometrial atrophy, which both involve a damaged endometrium. A review of existing literature was performed that confirmed the lack of consensus on endometrial therapeutic options, though promising new alternatives have emerged in recent years (platelet\u2010rich plasma, exosomes derived from stem cells, bioengineering\u2010based techniques, endometrial organoids, among others). In the future, basic research using established experimental models of endometrial pathologies (combined with new high\u2010tech solutions) and human clinical trials with large population sizes are needed to evaluate these emerging and new endometrial therapies.<\/jats:p>","DOI":"10.1002\/mrd.23523","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T16:51:16Z","timestamp":1626972676000},"page":"527-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Strategies for managing Asherman's syndrome and endometrial atrophy: Since the classical experimental models to the new bioengineering approach"],"prefix":"10.1002","volume":"88","author":[{"given":"Luc\u00eda","family":"de Miguel\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Instituto Valenciano de Infertilidad (FIVI) La Fe Health Research Institute  Valencia Spain"},{"name":"University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Romeu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Research Group, La Fe Health Research Institute La Fe University Hospital  Valencia Spain"},{"name":"Women's Health Area, Human Reproduction Unit La Fe University Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pellicer","sequence":"additional","affiliation":[{"name":"University of Valencia  Valencia Spain"},{"name":"IVIRMA Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cervell\u00f3","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Instituto Valenciano de Infertilidad (FIVI) La Fe Health Research Institute  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14647270903377178"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1130-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/atr.37976"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096662"},{"key":"e_1_2_8_6_1","first-page":"175","article-title":"Effects of pentoxifylline and vitamin E on pregnancy rate in infertile women treated by ZIF: a randomized clinical trial","volume":"7","author":"Aleyasin A.","year":"2009","journal-title":"International journal of reproductive biomedicine"},{"key":"e_1_2_8_7_1","first-page":"125","article-title":"The role of intrauterine balloon after operative hysteroscopy in the prevention of intrauterine adhesions: A prospective controlled study","volume":"10","author":"Amer M. 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