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Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and expression of the corresponding ligand\u2010related genes in the endometrium. A total of 175 receptor genes were identified in the morula, including 48 encoding for growth factors or WNT signaling molecules, 25 for cytokines and chemokines, 35 involved in juxtacrine and matricellular signaling and 25 encoding for receptors for small molecules. Some of the highly\u2010expressed pairs of endometrial ligand and embryo receptor genes included <jats:italic>MDK<\/jats:italic> and its receptors <jats:italic>ITGB1, SDC4<\/jats:italic> and <jats:italic>LRP2<\/jats:italic>, <jats:italic>WNT5A<\/jats:italic> (<jats:italic>RYK<\/jats:italic>), <jats:italic>VEGFA<\/jats:italic> (<jats:italic>ITGB1), GPI<\/jats:italic> (<jats:italic>AMFR<\/jats:italic>), and the hedgehog proteins <jats:italic>IHH<\/jats:italic> and <jats:italic>DHH<\/jats:italic> (<jats:italic>HHIP<\/jats:italic>). The most highly expressed receptors for small molecules were <jats:italic>GPRC5C<\/jats:italic> (retinoic acid receptor), <jats:italic>PGRMC1<\/jats:italic> (progesterone), and <jats:italic>CHRNB2<\/jats:italic> (acetylcholine). There were also 84 genes encoding for cell signaling ligands expressed by the morula, with the most highly expressed being <jats:italic>GPI, AIMP1, TIMP1, IK<\/jats:italic>, and <jats:italic>CCN2<\/jats:italic>. The atlas of receptor and ligand genes should prove useful for understanding details of the communication between the embryo and mother that underlies optimal embryonic development.<\/jats:p>","DOI":"10.1002\/mrd.23534","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:17:01Z","timestamp":1633133821000},"page":"694-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Atlas of receptor genes expressed by the bovine morula and corresponding ligand\u2010related genes expressed by uterine endometrium"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-7311","authenticated-orcid":false,"given":"Lei","family":"Sang","sequence":"first","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural Sciences  Fuzhou Fujian China"},{"name":"Department of Animal Sciences, D.H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-6839","authenticated-orcid":false,"given":"Yao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Animal Science and Veterinary Medicine Shandong Academy of Agricultural Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-7771","authenticated-orcid":false,"given":"Zongliang","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Animal Sciences, AgCenter Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-9643","authenticated-orcid":false,"given":"Niamh","family":"Forde","sequence":"additional","affiliation":[{"name":"Department of Discovery and Translational Sciences University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8441-2154","authenticated-orcid":false,"given":"Xiuchun Cindy","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Animal Science University of Connecticut  Storrs Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-5044","authenticated-orcid":false,"given":"Patrick","family":"Lonergan","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science University College  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-9333","authenticated-orcid":false,"given":"Peter J.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, D.H. 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