{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:46:14Z","timestamp":1789566374878,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Europe, in the last 3 decades, there has been a constant increase in litter size due to the use of superior maternal line genetics. Those sows giving birth to more piglets than their average number of functional teats are identified as hyperprolific\u00a0sows\u00a0(HPS). The large number of piglets born within a litter implies not only a challenge for their access to vital resources like colostrum and milk but has a direct effect on their average birth weight and heterogeneity. These conditions are detrimental to piglets' vitality in the first hours of life and also to their immunity development. An exceptionally large number of growing fetuses in HPS leads to intrauterine crowding and consequently to an increased number of piglets suffering from intrauterine growth retardation (IUGR), which put piglets at a high risk of mortality after birth and up to later stages of life. Increased heterogeneity of birth weight within large litters increases the competition for colostrum intake, with the smaller piglets being less competitive and vital, and therefore affecting negatively their immunity. Low birth weight, long interval to reach the udder, and long duration of farrowing, all have negative effects on piglets' immunoglobulin absorption. In HPS litters, colostrum management should be focused on low birth weight piglets, anticipating their impaired capabilities associated with ingesting adequate colostrum, by shortening the time to reach the udder and reducing competition among piglets. The vitality of neonate piglets, especially low in birth weight or affected by IUGR should be enhanced to improve their body temperature and their early life stage energy metabolism.<\/jats:p>","DOI":"10.1002\/mrd.23572","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T01:48:52Z","timestamp":1650678532000},"page":"580-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Offspring of hyper prolific sows: Immunity, birthweight, and heterogeneous litters"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-9595","authenticated-orcid":false,"given":"Claudio","family":"Oliviero","sequence":"first","affiliation":[{"name":"Department of Production Animal Medicine, Faculty of Veterinary Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2133","article-title":"The effect of parity and litter size on birth weight and the effect of birth weight variations on weaning weight and pre\u2010weaning survival in piglet","volume":"8","author":"Akdag F.","year":"2009","journal-title":"Journal of Animal and Veterinary Advances"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2016-0639"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-6824"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/66152\/2011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7120\/09627286.22.2.219"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3920\/978-90-8686-894-0_3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2009-2222"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.01.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2009-2121"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-4426"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-3-42"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.animal.2021.100184"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2014.01.024"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2015.11.015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731117000131"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S175173110700016X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12133"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.217.79"},{"key":"e_1_2_7_20_1","first-page":"57","article-title":"Effect of migration, distribution and spacing of pig embryos on pregnancy and fetal survival","volume":"33","author":"Dziuk P.","year":"1985","journal-title":"Journal of Reproduction and Fertility"},{"key":"e_1_2_7_21_1","first-page":"207","volume-title":"Nutrition of hyperprolific sows","author":"Edwards S.","year":"2019"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2014.02.013"},{"key":"e_1_2_7_23_1","first-page":"205","article-title":"Hyperprolificacy and acceptable post\u2010natal development \u2013 a possible contradiction","volume":"19","author":"Foxcroft G.","year":"2008","journal-title":"Advances in Pork Production"},{"key":"e_1_2_7_24_1","first-page":"355","article-title":"Behavioural perspectives on piglet survival","volume":"40","author":"Fraser D.","year":"1990","journal-title":"Journal of Reproduction and Fertility"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00064"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2019.07.004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2018.08.037"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13264"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2014-8713"},{"key":"e_1_2_7_30_1","first-page":"19","article-title":"Passive immunization in neonatal piglets in natural rearing\u2014Effects of birth order, birth weight, litter size and parity","volume":"117","author":"Klobasa F.","year":"2004","journal-title":"Deutsche tier\u00e4rztliche Wochenschrift"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2017.08.015"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani8050060"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5424\/sjar\/2017152-9921"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2018.11.005"},{"key":"e_1_2_7_35_1","first-page":"239","article-title":"Effect of piglet separation from dam at birth on colostrum uptake","volume":"82","author":"Manjarin R.","year":"2018","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711-018-0417-7"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2017.06.006"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13264"},{"key":"e_1_2_7_39_1","unstructured":"Moustsen V. &Nielsen M.(2017).Mammary glands and teats on Danish sows\u00a0(Report No. 1117). SEGES The Danish Pig Research Center."},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.54846\/jshap\/775","article-title":"An investigation of the impacts of induced parturition, birth weight, birth order, litter size, and sow parity on piglet serum concentrations of immunoglobulin G","volume":"21","author":"Nguyen K.","year":"2013","journal-title":"Journal of Swine Health and Production"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skab054.254"},{"key":"e_1_2_7_42_1","first-page":"203","volume-title":"Control of pig reproduction IX","author":"Oliviero C.","year":"2013"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13463"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2016.12.009"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S175173110800308X"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2012.03.010"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-6226(02)00182-3"},{"key":"e_1_2_7_48_1","unstructured":"Rutherford K. Baxter E. Ask B. Berg P. D'Eath R. Jarvis S. Jensen K. Lawrence A. Moustsen V. &Robson S.(2011).The ethical and welfare implications of large litter size in the domestic pig: Challenges and solutions(Project Report\u00a0No. 17). Danish Centre for Bioethics and Risk Assessment (CeBRA).https:\/\/static-curis.ku.dk\/portal\/files\/37642367\/17_Ethics_welfare_pig_litter_size.pdf"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.7120\/09627286.22.2.199"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2018.10.018"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731113001249"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-5-55"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02510"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209233"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/tas\/txab016"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-017-0159-3"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.2527\/2002.8051311x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/10915810290096577"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skz223"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/1745039X.2012.683325"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrd.23572","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T20:23:56Z","timestamp":1727036636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.23572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":59,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/mrd.23572"],"URL":"https:\/\/doi.org\/10.1002\/mrd.23572","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,22]]},"assertion":[{"value":"2022-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}