{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:18:14Z","timestamp":1770661094467,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long noncoding RNA plasmacytoma variant translocation 1 (PVT1) is essential for the maintenance of normal functions of trophoblasts in preeclampsia (PE).\u00a0This study aims to decipher the concrete mechanism of PVT1 with the microRNA\u201024\u20103p\/Type\u20102 11\u03b2\u2010hydroxysteroid dehydrogenase (miR\u201024\u20103p\/HSD11B2) axis in PE. PVT1, miR\u201024\u20103p, and HSD11B2 expression levels in normal placental tissues and PE placental tissues were defined. HTR\u20108\/SVneo cells were transfected to determine the effects of PVT1, miR\u201024\u20103p, and HSD11B2 on the growth of HTR\u20108\/SVneo cells. The relationships among PVT1\/miR\u201024\u20103p\/HSD11B2 in HTR\u20108\/SVneo cells were identified. PVT1 and HSD11B2 were downregulated, while miR\u201024\u20103p was upregulated in the placenta of PE. Upregulated\/downregulated PVT1 promoted\/impeded the growth of human placental trophoblast (HTR\u20108\/SVneo) cells in PE. Restored\/knocked down miR\u201024\u20103p impeded\/enhanced the growth of HTR\u20108\/SVneo cells in PE. PVT1 inhibited miR\u201024\u20103p to mediate HSD11B2. PVT1 sponges miR\u201024\u20103p to regulate HSD11B2; thereby, the growth of placental trophoblasts is promoted in PE.<\/jats:p>","DOI":"10.1002\/mrd.23575","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T11:03:51Z","timestamp":1655982231000},"page":"271-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long noncoding RNA PVT1 accelerates the growth of placental trophoblasts in preeclampsia through the microRNA\u201024\u20103p\/HSD11B2 axis"],"prefix":"10.1002","volume":"89","author":[{"given":"Xiaoying","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Obstetrics Hubei Maternal and Child Health Hospital  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of gynaecology Hubei Maternal and Child Health Hospital, Wuhan  Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hubei Maternal and Child Health Hospital  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0473-5"},{"issue":"20","key":"e_1_2_7_3_1","first-page":"6905","article-title":"PVT1 protects diabetic peripheral neuropathy via PI3K\/AKT pathway","volume":"22","author":"Chen L.","year":"2018","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.688873"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117288"},{"issue":"13","key":"e_1_2_7_6_1","first-page":"5851","article-title":"MIR22HG inhibits cell growth, migration and invasion through regulating the miR\u201024\u20103p\/p27kip1 axis in thyroid papillary carcinomas","volume":"23","author":"Chen Z. 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