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IUGR piglets are born with low body weight and shape indicative of differences in organ growth. Insufficient uteroplacental nutrient transfer to the fetuses is the leading cause of growth restriction in the pig. Supplementing the sow's gestation diet with arginine and\/or glutamine improves placenta growth and functionality and consequently is able to reduce IUGR incidence. IUGR piglets are at higher risk of dying preweaning and face higher morbidity than their normal\u2010weight littermates. A high level of surveillance during farrowing and individual nutrient supplementation can reduce the mortality rates. Still, these do not reverse the long\u2010term consequences of IUGR, which are induced by persistent structural deficits in different organs. Dietary interventions peri\u2010weaning can optimize performance but these are less effective in combating the metabolic changes that occurred in IUGR, which affect reproductive performance later in life. IUGR piglets share many similarities with IUGR infants, such as a poorer outcome of males. Using the IUGR piglet as an animal model to further explore the structural and molecular basis of the long\u2010term consequences of IUGR and the potential sex bias could aid in fully understanding the impact of prenatal undernutrition and finding solutions for both species and sexes.<\/jats:p>","DOI":"10.1002\/mrd.23614","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T10:49:05Z","timestamp":1654166945000},"page":"697-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Preweaning performance in intrauterine growth\u2010restricted piglets: Characteristics and interventions"],"prefix":"10.1002","volume":"90","author":[{"given":"Chris","family":"Van Ginneken","sequence":"first","affiliation":[{"name":"Comparative Perinatal Development (CoPeD), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Antwerp 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