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The RNA\u2010binding dead end (Dnd) protein is necessary for the specification and migration of primordial germ cells to the future reproductive organs. Here, we ablated the gametes in Atlantic salmon males and females by microinjecting <jats:italic>dnd<\/jats:italic> antisense gapmer oligonucleotides at the zygotic stage. Precocious maturation was induced in above 50% of both germ cell\u2010depleted and intact fertile males, but not in females, by exposure to an off\u2010season photoperiod regime. Sterile and fertile males showed similar body growth, but maturing fish tended to be heavier than their immature counterparts. Pituitary <jats:italic>fsh\u03b2<\/jats:italic> messenger RNA levels strongly increased in maturing sterile and fertile males concomitant with the upregulated expression of Sertoli and Leydig cell markers. Plasma concentrations of 11\u2010ketotestosterone and testosterone in maturing sterile males were significantly higher than the basal levels in immature fish, but lower than those in maturing fertile males. The study demonstrates that germ cells are not a prerequisite for the activation of the brain\u2013pituitary\u2013gonad axis and sex steroidogenesis in Atlantic salmon males, but may be important for the maintenance of gonadal somatic functions.<\/jats:p>","DOI":"10.1002\/mrd.23635","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T16:55:35Z","timestamp":1657731335000},"page":"471-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of germ cell ablation on the activation of the brain\u2013pituitary\u2013gonadal axis in precocious Atlantic salmon (<i>Salmo\u00a0salar<\/i> L.) males"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-0178","authenticated-orcid":false,"given":"Helge","family":"Tveiten","sequence":"first","affiliation":[{"name":"Norwegian College of Fishery Science The Arctic University of Norway  Troms\u00f8 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