{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:47:48Z","timestamp":1791859668044,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endometrium decidualization is a complex biological process, which includes the interplay of transcription factors, cytokines, cell cycle regulators, and other signaling pathways. However, the underlying molecular mechanisms of this process are not fully elucidated to date. In this study, we aimed to investigate the possible association between autophagy and recurrent implantation failure (RIF). A total of 81 genes were downregulated and 231 genes were upregulated in the RIF group compared with the control group, and the differences were statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Further, Gene Ontology\u00a0and Kyoto Encyclopedia of Genes and Genomes\u00a0pathway were analyzed, and we found that some autophagy markers, for example, LC3\u2010II, LAMP2, and HIF\u20101\u03b1 were significantly increased, whereas P62 was drastically downregulated in the RIF group. Similar results were observed in proteins level; and the autophagy puncta were also markedly enhanced in the endometrial tissues of RIF patients. Autophagy is closely associated with the RIF occurs and may be involved in the pathogenesis of RIF.<\/jats:p>","DOI":"10.1002\/mrd.23654","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T13:45:00Z","timestamp":1670247900000},"page":"655-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Autophagy markers are dysregulated in the endometrial tissues of patients with unexplained repeated implantation failure"],"prefix":"10.1002","volume":"89","author":[{"given":"Yuanchang","family":"Zhu","sequence":"first","affiliation":[{"name":"Fertility Center Jiangxi Maternal and Child Health Hospital Nanchang China"},{"name":"Fertility Center Shenzhen Hengsheng Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fertility Center Jiangxi Maternal and Child Health Hospital Nanchang 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