{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:09:14Z","timestamp":1777378154406,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The goal for the present study was to investigate whether previous infection with severe acute respiratory syndrome coronavirus 2\u00a0(SARS\u2010CoV\u20102) may compromise embryo morphokinetics and implantation. For that, a historical cohort study was performed in a private university\u2010affiliated in vitro fertilization\u00a0center. The study included 1628 embryos from 88 patients undergoing intracytoplasmic sperm injection\u00a0(ICSI) cycles. Patients were age\u2010matched in a 1:3 ratio to either a coronavirus\u00a0disease (COVID)\u00a0group, including patients with a positive SARS\u2010CoV\u20102 immunoglobulin test (<jats:italic>n<\/jats:italic>\u2009=\u200922 patients, 386 embryos), or a control group, including patients with a negative SARS\u2010CoV\u20102 immunoglobulin test (<jats:italic>n<\/jats:italic>\u2009=\u200966, 1242 embryos). The effect of previous infection with SARS\u2010CoV\u20102 on morphokinetic events and ICSI outcomes was evaluated. Embryos derived from patients in the COVID\u00a0group presented longer time to pronuclei appearance and fading, time to form two, three, four and five cells, and time to blastulation. The durations of the third cell cycle and to time to complete synchronous divisions were also significantly increased in the COVID\u00a0group compared with the control\u00a0group, whereas\u00a0known implantation diagnosis\u00a0score Day 5 ranked significantly lower in the COVID\u00a0group. No differences were observed between the COVID and control groups on clinical outcomes. In conclusion, patients planning parenthood, who have recovered from COVID\u201019 infection, must be aware of a possible effect of the infection on embryo development potential.<\/jats:p>","DOI":"10.1002\/mrd.23658","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T19:09:46Z","timestamp":1672254586000},"page":"53-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Previous infection with SARS\u2010CoV\u20102 impacts embryo morphokinetics but not clinical outcomes\u00a0in a time\u2010lapse imaging system"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-6593","authenticated-orcid":false,"given":"Daniela P. A. 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