{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:51:05Z","timestamp":1790139065222,"version":"4.0.1"},"reference-count":78,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012620","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid autoimmunity (TAI) triggered by genetic and epigenetic variation occurs mostly in women of reproductive age. TAI is described mainly by positivity of anti\u2010thyroid peroxidase antibody (TPO\u2010Ab) and\/or thyroglobulin antibody (TG\u2010Ab). TPO\u2010Ab, but not TG\u2010Ab, was suggested to be associated with pregnancy outcome in euthyroid women undergoing assisted reproductive technology (ART), but their results are conflicting. This meta\u2010analysis was performed to decide whether the presence of TPO\u2010Ab\u2014in a concentration dependent manner\u2014correlates with the success of ART. A systematic literature search was performed in the PubMed, Web of Science, and EMBASE databases for relevant articles published from January 1999 to April 2022, and these studies focused on the effect of TAI on pregnancy outcomes of women who underwent in vitro fertilization, intracytoplasmic sperm injection and intrauterine insemination and met the inclusion criteria: (i) the studies were prospective or retrospective study; (ii) all patients undergoing ART were tested for thyroid\u2010related antibodies; (iii) the assessed ART outcomes included miscarriage rate (MR) or delivery rate (DR). The exclusion criteria were: (i) female congenital uterine malformation, chromosomal diseases and other infectious diseases; (ii) overt hypothyroidism or pre\u2010existing thyroid disease; (iii) thrombus tendency. We divided the included patients into three groups according to the TPO\u2010Ab threshold they defined: (i) TPO\u2010Ab (\u2212), threshold &lt;34 IU\/mL; (ii) TPO\u2010Ab\u201034, threshold &gt;34 IU\/mL; (iii) TPO\u2010Ab\u2010100, threshold &gt;100 IU\/mL. We then extracted necessary relevant data, including MR and DR. Egger's test was used to evaluate the risk of publication bias. This meta\u2010analysis included a total of 7 literatures involving 7466 patients with TAI (\u2212) and 965 patients with TAI (+) and revealed that there was no significant difference between group TPO\u2010Ab\u201034 and group TPO\u2010Ab (\u2212) in MR [risk ratio (RR): 0.61 (0.35, 1.08), <jats:italic>p<\/jats:italic>\u2009=\u20090.09] and DR [RR: 0.97 (0.83, 1.13), <jats:italic>p<\/jats:italic>\u2009=\u20090.69]. By contrast, compared to TPO\u2010Ab (\u2212) group, TPO\u2010Ab\u2010100 patients showed markedly higher MR [RR: 2.12 (1.52, 2.96), <jats:italic>p<\/jats:italic>\u2009=\u20090.0046], and lower DR [RR: 0.66 (0.49, 0.88), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001] with high degree of statistical significance. This meta\u2010analysis suggests that, for euthyroid patients, high level of TPO\u2010Ab (&gt;100 IU\/mL) could adversely influence the pregnancy outcome of ART.<\/jats:p>","DOI":"10.1002\/mrd.23677","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T06:09:02Z","timestamp":1678946942000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High level of thyroid peroxidase antibodies as a detrimental risk of pregnancy outcomes in euthyroid women undergoing ART: A meta\u2010analysis"],"prefix":"10.1002","volume":"90","author":[{"given":"Sudan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingdong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Shouguang People's Hospital Shouguang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao Branch of SJTU Bio\u2010X Institutes The Affiliated Hospital of Qingdao University Qingdao Shandong China"},{"name":"Department of Toxicology, School of Public Health Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The People's Hospital of Shinan District Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Cell Biology, Basic Medical College Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Yale Stem Cell Center Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-5983","authenticated-orcid":false,"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China"},{"name":"Department of Genetics and Cell Biology, Basic Medical College Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiane","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China"},{"name":"Department of Genetics and Cell Biology, Basic Medical College Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e904e5"},{"issue":"6","key":"e_1_2_6_3_1","article-title":"Thyroxine replacement for subfertile women with euthyroid autoimmune thyroid disease or subclinical hypothyroidism","volume":"6","author":"Akhtar M. 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