{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:12:44Z","timestamp":1790799164977,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The goal for the present study was to investigate the effect of aneuploidy on embryo morphokinetics events in a time\u2010lapse imaging (TLI) system incubator. This retrospective cohort study was performed in a private university\u2010affiliated in vitro fertilization center, between 2019 March and December 2020. Kinetic data were analyzed in 935 embryos, derived from 316 patients undergoing intracytoplasmic sperm injection cycle with preimplantation genetic testing (PGT) for aneuploidy, individually cultured in a TLI incubator until Day 5 of development. Timing of morphokinetic variables, the incidences of multinucleation, and Known Implantation Data Score (KIDScore)\u2010Day 5 were compared between euploid (<jats:italic>n<\/jats:italic>\u2009=\u2009352) and aneuploid embryos (<jats:italic>n<\/jats:italic>\u2009=\u2009583). Aneuploid embryos showed significantly longer timing to complete specific morphokinetic parameters compared to euploidy embryos. Euploidy embryos also showed a significantly higher KIDScore when compared with the aneuploidy ones. Our evidence suggests that TLI monitoring may be an adjunct approach to select embryos for PGT; however, cautious investigation is still needed.<\/jats:p>","DOI":"10.1002\/mrd.23692","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T10:58:48Z","timestamp":1687172328000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Time\u2010lapse monitoring: An adjunct tool to select embryos for preimplantation genetic testing"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-6593","authenticated-orcid":false,"given":"Daniela P. de Almeida Ferreira","family":"Braga","sequence":"first","affiliation":[{"name":"Fertility Medical Group S\u00e3o Paulo Brazil"},{"name":"Sapientiae Institute \u2013 Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-5285","authenticated-orcid":false,"given":"Amanda S.","family":"Setti","sequence":"additional","affiliation":[{"name":"Fertility Medical Group S\u00e3o Paulo Brazil"},{"name":"Sapientiae Institute \u2013 Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Guilherme","sequence":"additional","affiliation":[{"name":"Fertility Medical Group S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Morishima","sequence":"additional","affiliation":[{"name":"Sapientiae Institute \u2013 Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Assumpto","family":"Iaconelli","sequence":"additional","affiliation":[{"name":"Fertility Medical Group S\u00e3o Paulo Brazil"},{"name":"Sapientiae Institute \u2013 Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Edson","family":"Borges","sequence":"additional","affiliation":[{"name":"Fertility Medical Group S\u00e3o Paulo Brazil"},{"name":"Sapientiae Institute \u2013 Centro de Estudos e Pesquisa em Reprodu\u00e7\u00e3o Humana Assistida S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.04.041"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0813-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.04.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des394"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaw056"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2249"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0372-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199418000084"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.12.025"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.06.030"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1309-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu064"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu130"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/35066065"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0285-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu175"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez055"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz033"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.05.020"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew183"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.11.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.09.019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92425-F"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.02.012"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.183511"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.09.012"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1265-7"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.04.039"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det314"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat039"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-7-38"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex234"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-0965-8"}],"container-title":["Molecular Reproduction and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrd.23692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T14:25:03Z","timestamp":1692282303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrd.23692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/mrd.23692"],"URL":"https:\/\/doi.org\/10.1002\/mrd.23692","archive":["Portico"],"relation":{},"ISSN":["1040-452X","1098-2795"],"issn-type":[{"value":"1040-452X","type":"print"},{"value":"1098-2795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}