{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T04:47:19Z","timestamp":1692334039846},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preeclampsia is an obstetric disorder and remains the leading contributor to maternal and fetal morbidity and mortality. This study was designed to explore the role of hsa_circ_0001740 in preeclampsia as well as its underlying mechanism. Real\u2010time quantitative polymerase chain reaction was performed to examine hsa_circ_0001740 and miR\u2010188\u20103p levels in trophoblast cell line HTR\u20108\/SVneo. The proliferation, migration, invasion, and apoptosis of HTR\u20108\/SVneo cells were detected using cell counting kit\u20108, colony formation, wound healing, transwell, and terminal\u2010deoxynucleoitidyl transferase mediated nick end labeling assays, respectively. The expression of apoptosis\u2010 and Hippo signaling\u2010related proteins were assessed by western blot. Moreover, the binding relationship between hsa_circ_0001740 and miR\u2010188\u20103p, miR\u2010188\u20103p and ARRDC3 were verified by luciferase report assay. The results showed that hsa_circ_001740 overexpression inhibited the proliferation, migration, and invasion, and promoted apoptosis of HTR\u20108\/SVneo cells. Hsa_circ_0001740 was verified to bind to miR\u2010188\u20103p, and ARRDC3 was demonstrated to be a target of miR\u2010188\u20103p. miR\u2010188\u20103p overexpression partially counteracted the suppressive effects of hsa_circ_001740 overexpression on the proliferation, migration, and invasion of HTR\u20108\/SVneo cells. What's more, ARRDC3 expression was upregulated by hsa_circ_001740\u2010overexpression but was downregulated by miR\u2010188\u20103p overexpression. Hsa_circ_001740\/miR\u2010188\u20103p also mediated Hippo signaling. To summarize, hsa_circ_0001740 could maintain trophoblast cell function via downregulating miR\u2010188\u20103p, providing a potential biomarker for the diagnosis and treatment of preeclampsia.<\/jats:p>","DOI":"10.1002\/mrd.23695","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T13:16:22Z","timestamp":1689167782000},"page":"406-416","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hsa_circ_0001740 mediates trophoblast cell function via regulating miR\u2010188\u20103p\/ARRDC3"],"prefix":"10.1002","volume":"90","author":[{"given":"Mei","family":"Long","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Inner Mongolia People's Hospital  Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Maternal Health Jinhua Maternal and Child Health Care Hospital  Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.09.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.664766"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml048"},{"issue":"6","key":"e_1_2_8_6_1","first-page":"1533","article-title":"MiR\u20104421 regulates the progression of preeclampsia by regulating CYP11B2","volume":"22","author":"Gao X.","year":"2018","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11993"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/186041","article-title":"Circulating C19MC microRNAs in preeclampsia, gestational hypertension, and fetal growth restriction","volume":"2013","author":"Hromadnikova I.","year":"2013","journal-title":"Mediators of Inflammation"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201019666180427110547"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0482-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.119176"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489685"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.09.033"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7237495","article-title":"Role of circular RNAs in preeclampsia","volume":"2019","author":"Jia N.","year":"2019","journal-title":"Disease Markers"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.07.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2019.10.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120121"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.11.005"},{"issue":"10","key":"e_1_2_8_19_1","first-page":"5223","article-title":"MiRNA\u2010203a\u20103p inhibits inflammatory response in preeclampsia through regulating IL24","volume":"24","author":"Ma H. 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