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Autophagy is necessary for cellular survival in the face of environmental stress as well as cellular homeostasis and energy management. Aberrant microRNA (miRNA) expression is crucial in the pathophysiology of PE. Although studies have shown that miRNA (miR)\u2010190a\u20103p function is tissue\u2010specific, the precise involvement of miR\u2010190a\u20103p in PE has yet to be determined. We discovered that miR\u2010190a\u20103p was significantly lower and death\u2010associated protein kinase 1 (DAPK1) was significantly higher in PE placental tissues compared to normal tissues, which is consistent with the results in cells. The luciferase analyses demonstrated the target\u2010regulatory relationship between miR\u2010190a\u20103p and DAPK1. The inhibitory effect of miR\u2010190a\u20103p on autophagy was reversed by co\u2010transfection of si\u2010DAPK1 and miR\u2010190a\u20103p inhibitors. Thus, our data indicate that the hypoxia\u2010dependent miR\u2010190a\u20103p\/DAPK1 regulatory pathway is implicated in the development and progression of PE by promoting autophagy in trophoblast cells.<\/jats:p>","DOI":"10.1002\/mrd.23724","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T05:28:27Z","timestamp":1706074107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The targeting of DAPK1 with miR\u2010190a\u20103p promotes autophagy in trophoblast cells"],"prefix":"10.1002","volume":"91","author":[{"given":"Qi\u2010qi","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Gerontology First Affiliated Hospital of Harbin Medical University Harbin People's Republic of China"},{"name":"Department of Cardiovascular Medicine, Army Characteristic Medical Center of PLA Da ping Hospital  Chongqing People's Republic of 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