{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T14:01:14Z","timestamp":1762783274746,"version":"3.44.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study investigated the effect of Bushen Shengjing Decoction (BSSJD) to modulate SCF\/c\u2010kit signaling pathway\u2010mediated apoptosis on spermatogenesis in rats with oligoasthenospermia (OAS). The glucoside of Tripterygium wilfordii Hook F was given by gavage administration for OAS modeling in rats. The modeled rats were administered by gavage with BSSJD at different doses. Blood was collected from the abdominal aorta. The effect of BSSJD on OAS rats was determined by measuring serum testosterone (T), estradiol (E2) and luteinizing hormone (LH), epididymal index and testicular index, and sperm concentration and viability. Pathological changes in testicular tissues were observed. Caspase\u20103, Bax and Bcl\u20102 mRNA levels, along with SCF and c\u2010kit levels in the testis tissues of rats were measured. BSSJD improved sperm concentration and quality, increased T and E2 levels, and reduced LH levels in rats with OAS. BSSJD alleviated apoptosis by decreasing Bax and caspase\u20103 and increasing Bcl\u20102 in testicular tissues of rats with OAS. Isck03 reversed the improvement of spermatogenesis and apoptosis in OAS rats treated with BSSJD. BSSJD improves spermatogenic function in OAS rats, which may act by regulating SCF\/c\u2010kit signaling pathway\u2010mediated apoptosis.<\/jats:p>","DOI":"10.1002\/mrd.70044","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T14:12:52Z","timestamp":1754921572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanism of Bushen Shengjing Decoction on the Spermatogenic Function of in Rats With Oligoasthenospermia: Focus on SCF\/c\u2010Kit Signaling Pathway\u2010Mediated Apoptosis"],"prefix":"10.1002","volume":"92","author":[{"given":"Bo","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"He","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueling","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2677-3191","authenticated-orcid":false,"given":"Guanghui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12806"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32667-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.253"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22430"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-017-0399-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1139450"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0481"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1056091"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1543405"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202201159"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.11.026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00401-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.proghi.2014.09.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(15)30072-8"},{"key":"e_1_2_9_16_1","first-page":"3","article-title":"Clinical Efficacy of QiZi Oral Liquid for Tonifying Kidney And Promoting Spermatogenesis Combined With Tamoxifen and Vitamin E in The Treatment of Oligospermia and Asthenospermia","volume":"8","author":"Guan L.","year":"2016","journal-title":"Chinese Journal of Family Planning & Gynecology"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112525"},{"issue":"1","key":"e_1_2_9_18_1","first-page":"36","article-title":"Reproductive Systemic Toxicity and Mechanism of Glucosides of Tripterygium Wilfordii Hook. 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