{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:19:10Z","timestamp":1766985550935,"version":"3.48.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Reproduction Devel"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes\u2010associated spermatogenic dysfunction remains mechanistically unclear despite its clinical significance. We aimed to elucidate the effect and molecular mechanism of sperm damage induced by type 2 diabetes mellitus (T2DM). In a mouse model of T2DM, transcriptome sequencing identified\n                    <jats:italic>Art1<\/jats:italic>\n                    as a differentially expressed gene. T2DM induced structural damage to the seminiferous tubules, deregulated sperm parameters, and suppressed\n                    <jats:italic>Art1<\/jats:italic>\n                    expression in mice and caused reproductive damage in their offspring. Danshensu administration rescued these pathologies.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , high\u2010glucose\/high\u2010lipid exposure induced GC\u20102 cell damage, while\n                    <jats:italic>Art1<\/jats:italic>\n                    overexpression reduced oxidative stress and apoptosis.\n                    <jats:italic>Art1<\/jats:italic>\n                    \u2010knockout mice exhibited impaired sperm motility and tubule structural defects, confirming\n                    <jats:italic>Art1<\/jats:italic>\n                    's critical role in spermatogenesis maintenance. This study demonstrated that T2DM triggers testicular oxidative stress, apoptosis, and\n                    <jats:italic>Art1<\/jats:italic>\n                    suppression, leading to transgenerational reproductive dysfunction. Experiments have shown that the overexpression of Danshensu or\n                    <jats:italic>Art1<\/jats:italic>\n                    can rescue these pathological damages. The results from the\n                    <jats:italic>Art1<\/jats:italic>\n                    \u2010knockout mice confirm the indispensable regulatory role of\n                    <jats:italic>Art1<\/jats:italic>\n                    in spermatogenesis maintenance. We speculate that T2DM may impair male reproductive ability by inhibiting the expression of\n                    <jats:italic>Art1<\/jats:italic>\n                    , which will provide a new molecular target and theoretical basis for further investigation into the interaction mechanism between T2DM and the reproductive system.\n                  <\/jats:p>","DOI":"10.1002\/mrd.70076","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:59:57Z","timestamp":1765259997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of\n                    <i>Art1<\/i>\n                    in Sperm Damage Induced by Type 2 Diabetes Mellitus"],"prefix":"10.1002","volume":"92","author":[{"given":"Shumin","family":"Xu","sequence":"first","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinran","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"},{"name":"Anhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-485X","authenticated-orcid":false,"given":"Meng","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Life Science Bengbu Medical University Bengbu China"},{"name":"Anhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology (Reproductive Medicine Center), The First Affiliated Hospital Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","first-page":"524","article-title":"1 in 6 People Globally Affected by Infertility: WHO","volume":"44","author":"WHO Media Team","year":"2023","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.S241099"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051728"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000022733"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00459-w"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12336"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36664"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12531"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.101930"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23179"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-021-03474-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-016-0093-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-023-01232-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-016-0102-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1345589"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14031"},{"issue":"6","key":"e_1_2_11_18_1","first-page":"401","article-title":"Type 2 Diabetes Mellitus in Children and Adolescents","volume":"45","author":"Kao K. 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