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This study investigated\n                    <jats:italic>N\u2010(2\u2010hydroxy\u20103\u2010piperidin\u20101\u2010ylpropoxy)pyridine\u20103\u2010carboximidamide; dihydrochloride<\/jats:italic>\n                    (BGP\u201015), a mitochondrial modulator, as a follicular growth stimulator and a collagen\u2010depositing inhibitor, thereby improving graft quality. In vitro, neonatal mouse ovaries were treated with different concentrations of BGP\u201015. In vivo, adult mice undergoing ovarian autotransplantation received 10\u2009mg\/kg of BGP\u201015. Follicular quantification, gene expression by qRT\u2010PCR (\n                    <jats:italic>Sirt1<\/jats:italic>\n                    ,\n                    <jats:italic>Sirt3<\/jats:italic>\n                    ,\n                    <jats:italic>Nampt<\/jats:italic>\n                    ,\n                    <jats:italic>Foxo3a<\/jats:italic>\n                    ,\n                    <jats:italic>KitL<\/jats:italic>\n                    ,\n                    <jats:italic>Pten<\/jats:italic>\n                    ,\n                    <jats:italic>Amh<\/jats:italic>\n                    ), collagen deposition by Picrosirius assay, neoangiogenesis, macrophage infiltration, biometric parameters, and the estrous cycle were evaluated. In vitro, 0.001\u2009\u00b5M BGP\u201015 induced follicular growth. reducing the percentage of primordial follicles (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and upregulating\n                    <jats:italic>Sirt1<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001),\n                    <jats:italic>Sirt3<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026),\n                    <jats:italic>Nampt<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002),\n                    <jats:italic>Pten<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012), and downregulating\n                    <jats:italic>Amh<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031). In vivo, BGP\u201015 treatment in transplanted mice resulted in an earlier resumption of the estrous cycle (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0458). After transplantation, BGP\u201015 improved follicular outcome on day 22, increasing healthy follicles (transitional\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0206; primary\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0125; secondary\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0428) and reducing atretic follicles (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0381). Treated animals exhibited decreased macrophage numbers (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and collagen deposition (ovary:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0465; capsule:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0344), and increased blood vessel density (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). BGP\u201015 improves follicular growth and survival in ovarian grafts, coinciding with mitochondrial gene dysregulation and reduced collagen deposition. These findings suggest BGP\u201015 as a promising candidate for improving follicular outcomes after ovarian transplantation.\n                  <\/jats:p>","DOI":"10.1002\/mrd.70128","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:31:04Z","timestamp":1783837864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BGP\u201015 Treatment Improves Follicle Growth and Alters Collagen Deposition in Mouse Transplanted Ovaries"],"prefix":"10.1002","volume":"93","author":[{"given":"Luiza Aparecida Ansaloni Chagas","family":"Pereira","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Biology Research, Department of Natural Sciences Federal University of S\u00e3o Jo\u00e3o del Rei. S\u00e3o Jo\u00e3o Del\u2010Rei Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Aline","family":"Freitas","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Biology Research, Department of Natural Sciences Federal University of S\u00e3o Jo\u00e3o del Rei. S\u00e3o Jo\u00e3o Del\u2010Rei Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Stefane","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Biology Research, Department of Natural Sciences Federal University of S\u00e3o Jo\u00e3o del Rei. S\u00e3o Jo\u00e3o Del\u2010Rei Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine Stephany Serpa Amaral","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Biology Research, Department of Natural Sciences Federal University of S\u00e3o Jo\u00e3o del Rei. 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