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Microorganisms may also gain access to the fetus before delivery. A fetal inflammatory response syndrome elicited in response to microbial products is associated with the impending onset of preterm labor and also with multi\u2010systemic organ involvement in the human fetus and a higher rate of perinatal morbidity. The most common microorganisms involved in intrauterine infections are <jats:italic>Ureaplasma urealyticum<\/jats:italic>, <jats:italic>Fusobacterium<\/jats:italic> species and <jats:italic>Mycoplasma hominis<\/jats:italic>. The role of <jats:italic>Chlamydia trachomatis<\/jats:italic> and viruses in preterm labor remain to be determined. Use of molecular microbiology techniques to diagnose intrauterine infection may uncover the role of fastidious microorganisms that have not yet been discovered. Antibiotic administration to patients with asymptomatic bacteriuria is associated with a significant reduction in the rate of preterm birth. However, such benefit has not been demonstrated for patients with bacterial vaginosis, or women who carry <jats:italic>Streptococcus agalactia<\/jats:italic>, <jats:italic>Ureaplasma urealyticum<\/jats:italic> or <jats:italic>Trichomonas vaginalis<\/jats:italic>. Antibiotic administration to patients with preterm premature rupture of membranes is associated with prolongation of pregnancy and a reduction in the rate of clinical chorioamnionitis and neonatal sepsis. The benefit has not been demonstrated in patients with preterm labor and intact membranes. Major efforts are required to determine why some women develop an ascending intrauterine infection and others do not and also what interventions may reduce the deleterious effect of systemic fetal inflammation. MRDD Research Reviews 2002;8:3\u201313. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrdd.10008","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:12:15Z","timestamp":1030317135000},"page":"3-13","source":"Crossref","is-referenced-by-count":479,"title":["Intrauterine infection and prematurity"],"prefix":"10.1002","volume":"8","author":[{"given":"Lu\u00eds 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