{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:11:10Z","timestamp":1792062670242,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T00:00:00Z","timestamp":1094515200000},"content-version":"vor","delay-in-days":129,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ment. Retard. Dev. Disabil. Res. Rev."],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The occurrence of developmental regression in autism is one of the more puzzling features of this disorder. Although several studies have documented the validity of parental reports of regression using home videos, accumulating data suggest that most children who demonstrate regression also demonstrated previous, subtle, developmental differences. Counter to clinical intuition, the earlier development of social, language, and attachment behaviors followed by regression does not seem to support later recovery of skills or better developmental outcomes compared to children who never had speech or typical social responsivity. In fact, this regressive group may have somewhat greater developmental impairment than the nonregressive group, though the two groups do not appear to present different behavioral phenotypes. Although autism is not the only condition in which regression occurs, it appears to be the most frequent condition. Other disorders that demonstrate an early regression with no known etiology include total blindness from birth and childhood disintegrative disorder, both of which demonstrate behavioral relations to autism. In addition, two biological conditions with known etiologies also involve regression with some behaviors resembling autism behavioral phenotype: Rett syndrome (a genetic disorder; see Glaze, this issue) and Landau\u2013Kleffner syndrome (see McVicar and Shinnar, this issue), which involves a seizure disorder. MRDD Research Reviews 2004;10:139\u2013143. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrdd.20027","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T08:22:41Z","timestamp":1095150161000},"page":"139-143","source":"Crossref","is-referenced-by-count":136,"title":["Developmental regression in autism spectrum disorders"],"prefix":"10.1002","volume":"10","author":[{"given":"Sally J.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.3.192"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005403421141"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510030085013"},{"key":"e_1_2_1_5_1","first-page":"397","article-title":"Relation between blindness due to retinopathy of prematurity and autistic spectrum disorders: A population\u2010based study","volume":"40","author":"Ek U","year":"1998","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.4.e58"},{"key":"e_1_2_1_7_1","volume-title":"Insights from the Blind: Comparative Studies of Blind and Sighted Infants","author":"Fraiberg S","year":"1977"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199105000-00004"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JADD.0000005998.47370.ef"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7358(98)00094-4"},{"key":"e_1_2_1_11_1","first-page":"237","article-title":"Clinical features of autistic children with setback course in their infancy","volume":"41","author":"Hoshino Y","year":"1987","journal-title":"Jpn J Psychol Neurol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1998.tb10087.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-7138(09)60447-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01058149"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10615"},{"key":"e_1_2_1_16_1","article-title":"Early regression in social communication in autism spectrum disorders. ACPEA study.","author":"Luyster R.","journal-title":"Developmental Neuropsychology"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029102"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-002-0270-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1998.tb15395.x"},{"key":"e_1_2_1_20_1","unstructured":"OzonoffS WilliamsBJ et al. (in press).Parental report of the early development of children with regressive autism."},{"key":"e_1_2_1_21_1","article-title":"Is there a regressive 'Phenotype' of autism spectrum disorder associated with the measles\u2010mumps\u2010rubella vaccine? A CPEA study","author":"Richler J","journal-title":"Journal of Autism and Developmental Disorders"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199011000-00004"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1989.tb04045.x"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00266-6"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02211947"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7334.393"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010763502253"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.560"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.142.12.1450"},{"key":"e_1_2_1_30_1","article-title":"Variation in early developmental course in autism and its relation with behavioral outcome at 3\u20134 years of age","author":"Werner E","journal-title":"J Autism Dev Disord"},{"key":"e_1_2_1_31_1","unstructured":"WernerE MunsonJ.2001.Regression in autism: A description and validation of the phenomenon using parent report and home video tapes. 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