{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:04:57Z","timestamp":1790395497310,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,3,28]],"date-time":"2002-03-28T00:00:00Z","timestamp":1017273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A high\u2010resolution spin\u2010echo imaging method is presented (called CP\u2010LASER) which exploits the spin refocusing capability of an adiabatic Carr\u2010Purcell (CP) pulse sequence to measure apparent <jats:sup>1<\/jats:sup>H<jats:sub>2<\/jats:sub>O transverse relaxation (<jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-3.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM10112:tex2gif-stack-3\"\/>) and generate contrast based on microscopic tissue susceptibility. High\u2010resolution CP\u2010LASER images of the human occipital lobe were acquired at four different echo times from six subjects at 4T and eight subjects at 7T to investigate the effect of magnetic field strength (<jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub>) and the CP interpulse time (\u03c4<jats:sub>cp<\/jats:sub>) on <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-4.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM10112:tex2gif-stack-4\"\/>. Susceptibility contrast was identified and <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-5.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM10112:tex2gif-stack-5\"\/> was quantified for long \u03c4<jats:sub>cp<\/jats:sub> (&gt;10 ms) and short \u03c4<jats:sub>cp<\/jats:sub> (7 ms at 4T and 6 ms at 7T) in gray matter, white matter, and cerebral spinal fluid. The <jats:sup>1<\/jats:sup>H<jats:sub>2<\/jats:sub>O relaxation rate constants (1\/<jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-6.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM10112:tex2gif-stack-6\"\/>) of gray and white matter each increased approximately linearly with field strength and <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-7.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM10112:tex2gif-stack-7\"\/> was inversely related to \u03c4<jats:sub>cp<\/jats:sub>. The average <jats:italic>T<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-8.gif\" xlink:title=\"urn:x-wiley:07403194:media:MRM10112:tex2gif-stack-8\"\/> value of gray matter was 19% and 9% <jats:italic>smaller<\/jats:italic> than that of white matter at 4T and 7T, respectively. These results are consistent with higher levels of compartmentalized ferritin and increased blood volume in gray matter compared to white matter in this region of the brain. Magn Reson Med 47:742\u2013750, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.10112","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:15:07Z","timestamp":1030317307000},"page":"742-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["In vivo <sup>1<\/sup>H<sub>2<\/sub>O <i>T<\/i> measurement in the human occipital lobe at 4T and 7T by Carr\u2010Purcell MRI: Detection of microscopic susceptibility contrast"],"prefix":"10.1002","volume":"47","author":[{"given":"Robert","family":"Bartha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalom","family":"Michaeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellmut","family":"Merkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Adriany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Ugurbil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Garwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,28]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320610"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1727703"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1135"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.94.630"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910170207"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910170206"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310605"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310103"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910160103"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(94)00138-S"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350410"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<237::AID-MRM10>3.0.CO;2-5"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350304"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350108"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320309"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880050514"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330410"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1873"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330215"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300121"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199907000-00012"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.2001.2340"},{"key":"e_1_2_8_24_2","first-page":"41","article-title":"Studies of diffusion in random fields produced by variations in susceptibility","volume":"78","author":"Majumdar S","year":"1998","journal-title":"J Magn Reson"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310103"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(88)90022-4"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(84)90181-1"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmra.1996.0110"},{"key":"e_1_2_8_29_2","unstructured":"AdrianyG YacoubE TkacI AndersenP MerkleH VaughanJT UgurbilK.Shielded surface coils and half volume cavity resonators for imaging and spectroscopy applications at 7 Tesla. 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