{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:43:32Z","timestamp":1788518612839,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T00:00:00Z","timestamp":1036368000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heroin has been hypothesized to activate opiate receptors and inhibit \u03b3\u2010aminobutyric acid (GABA) release from inhibitory GABAergic interneurons which, in turn, activates dopamine projection cells. Since the distal sites and consequences of this disinhibition are not well understood on a systems level, heroin\u2010induced brain activity was measured using functional MRI (fMRI) in rats. A significant blood oxygen level\u2010dependent (BOLD) signal increase was seen in cortical regions, including prefrontal cortex, cingulate, and olfactory cortex following acute heroin administration. In contrast, a significant signal decrease was seen in several subcortical areas, including the caudate and putamen, nucleus accumbens, thalamus, and hypothalamus. Pretreatment of \u03b3\u2010vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, significantly attenuated the heroin\u2010induced BOLD signal changes. Pretreatment of naloxone, an opiate \u03bc receptor antagonist, eliminated the heroin\u2010induced BOLD signal changes and posttreatment of naloxone reversed the heroin\u2010induced BOLD signal changes. It is suggested that the heroin\u2010induced negative and positive BOLD changes are due to direct inhibitory and indirect disinhibitory mechanisms of GABAergic activities. Administration of GVG altered these mechanisms and further suggested that involvement of the opiate's pharmacological actions can, at least in part, be mediated by inhibiting brain GABA release. Magn Reson Med 48:838\u2013843, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.10282","type":"journal-article","created":{"date-parts":[[2002,11,5]],"date-time":"2002-11-05T14:07:43Z","timestamp":1036505263000},"page":"838-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["GABAergic mechanisms of heroin\u2010induced brain activation assessed with functional MRI"],"prefix":"10.1002","volume":"48","author":[{"given":"Zheng\u2010Xiong","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot 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