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In all studies, GSH was clearly detected with a spectral pattern consistent with spectra acquired from a phantom containing GSH. Retention of singlet resonances in the subspectra, a key advantage of this difference\u2010editing technique, provided an unambiguous reference for the offset and phase of the edited signal. Linear combination model (LCModel) analysis provided an unbiased means for quantifying signal contribution from edited metabolites. GSH concentration was estimated from the in vivo spectra as 1.3 \u00b1 0.2 \u03bcmol\/g (mean \u00b1 SD, n = 12). Magn Reson Med 50:19\u201323, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.10499","type":"journal-article","created":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T10:13:41Z","timestamp":1055758421000},"page":"19-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference\u2010edited spectra"],"prefix":"10.1002","volume":"50","author":[{"given":"Melissa","family":"Terpstra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Gilles","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Gruetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,13]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"911","volume-title":"Basic neurochemistry","author":"Yudkoff M","year":"1999"},{"key":"e_1_2_7_3_2","first-page":"592","volume-title":"Glutathione serves as a sulfhydryl buffer and amino acid transporter. 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