{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:38:20Z","timestamp":1792733900856,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,7,17]],"date-time":"2003-07-17T00:00:00Z","timestamp":1058400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During brain activation, local control of oxygen delivery is facilitated through microvascular dilatation and constriction. A new functional MRI (fMRI) methodology is reported that is sensitive to these microvascular adjustments. This contrast is accomplished by eliminating the blood signal in a manner that is independent of blood oxygenation and flow. As a consequence, changes in cerebral blood volume (CBV) can be assessed through changes in the remaining extravascular water signal (i.e., that of parenchymal tissue) without need for exogenous contrast agents or any other invasive procedures. The feasibility of this vascular space occupancy (VASO)\u2010dependent functional MRI (fMRI) approach is demonstrated for visual stimulation, breath\u2010hold (hypercapnia), and hyperventilation (hypocapnia). During visual stimulation and breath\u2010hold, the VASO signal shows an inverse correlation with the stimulus paradigm, consistent with local vasodilatation. This effect is reversed during hyperventilation. Comparison of the hemodynamic responses of VASO\u2010fMRI, cerebral blood flow (CBF)\u2010based fMRI, and blood oxygenation level\u2010dependent (BOLD) fMRI indicates both arteriolar and venular temporal characteristics in VASO. The effect of changes in water exchange rate and partial volume contamination with CSF were calculated to be negligible. At the commonly\u2010used fMRI resolution of 3.75 \u00d7 3.75 \u00d7 5 mm<jats:sup>3<\/jats:sup>, the contrast\u2010to\u2010noise\u2010ratio (CNR) of VASO\u2010fMRI was comparable to that of CBF\u2010based fMRI, but a factor of 3 lower than for BOLD\u2010fMRI. Arguments supporting a better gray matter localization for the VASO\u2010fMRI approach compared to BOLD are provided. Magn Reson Med 50:263\u2013274, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.10519","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T10:10:29Z","timestamp":1058523029000},"page":"263-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":456,"title":["Functional magnetic resonance imaging based on changes in vascular space occupancy"],"prefix":"10.1002","volume":"50","author":[{"given":"Hanzhang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Golay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Pekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.M.","family":"van 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