{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:03:55Z","timestamp":1791216235543,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T00:00:00Z","timestamp":1069372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In vivo longitudinal relaxation times of <jats:italic>N<\/jats:italic>\u2010acetyl compounds (NA), choline\u2010containing substances (Cho), creatine (Cr), <jats:italic>myo<\/jats:italic>\u2010inositol (mI), and tissue water were measured at 1.5 and 3 T using a point\u2010resolved spectroscopy (PRESS) sequence with short echo time (TE). <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> values were determined in six different brain regions: the occipital gray matter (GM), occipital white matter (WM), motor cortex, frontoparietal WM, thalamus, and cerebellum. The <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times of water protons were 26\u201338% longer at 3 T than at 1.5 T. Significantly longer metabolite <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> values at 3 T (11\u201336%) were found for NA, Cho, and Cr in the motor cortex, frontoparietal WM, and thalamus. The amounts of GM, WM, and cerebrospinal fluid (CSF) within the voxel were determined by segmentation of a 3D image data set. No influence of tissue composition on metabolite <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> values was found, while the longitudinal relaxation times of water protons were strongly correlated with the relative GM content. Magn Reson Med 50:1296\u20131301, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.10640","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T14:18:19Z","timestamp":1070374699000},"page":"1296-1301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["Comparison of longitudinal metabolite relaxation times in different regions of the human brain at 1.5 and 3 Tesla"],"prefix":"10.1002","volume":"50","author":[{"given":"Thomas","family":"Ethofer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Mader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Seeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunther","family":"Helms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Erb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Grodd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Klose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910110105"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1993.1056"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(93)90197-L"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940080305"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.762"},{"key":"e_1_2_6_7_2","unstructured":"BriefEE WhittallKP LiDKB MacKayAL.Metabolite T1 differs within and between regions of normal human brain. 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