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Measurements at the fluorine\u201019 Larmor frequency were performed in pigs using a gradient echo pulse sequence with 0.5 ms echo time and a measurement time of 9.1 s per image. Dynamic MRI was performed during wash\u2010in and wash\u2010out of SF<jats:sub>6<\/jats:sub> gas in mechanically ventilated porcine lungs. A postprocessing strategy was developed for quantitative determination of wash\u2010out time constants in the presence of noise. Mean wash\u2010out constants were 4.78 \u00b1 0.48 breaths vs. 4.33 \u00b1 0.76 breaths for left and right lung when ventilation was performed with low tidal volume, and 1.73 \u00b1 0.16 breaths vs. 1.85 \u00b1 0.11 breaths with high tidal volume ventilation. In conclusion, breath\u2010hold MRI of SF<jats:sub>6<\/jats:sub> gas is feasible in large animals. Moreover, regional wash\u2010in and wash\u2010out kinetics of SF<jats:sub>6<\/jats:sub> can be determined noninvasively with this new method. Potential human applications are discussed. 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