{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:06:04Z","timestamp":1760976364934},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,4,16]],"date-time":"2001-04-16T00:00:00Z","timestamp":987379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2001,5]]},"abstract":"Abstract<\/jats:title>The cytosol of intact human red blood cells was loaded with 28.1 \u00b1 3.4 mM of dysprosium DTPA\u2010BMA using a hypoosmotic technique. When loaded cells were diluted with saline and control cells to give an average dysprosium concentration of 3.3 \u00b1 0.5 mM, the transverse relaxation rate constants R<\/jats:italic> and R<\/jats:italic>2<\/jats:sub> increased. R<\/jats:italic> increased from 7.5 \u00b1 0.9 sec\u22121<\/jats:sup> to 356 \u00b1 50 sec\u22121<\/jats:sup>, and R<\/jats:italic>2<\/jats:sub> increased from 7.4 \u00b1 0.7 sec\u20131<\/jats:sup> to 148 \u00b1 40 sec\u22121<\/jats:sup>. After lysing, R<\/jats:italic> was 6.0 \u00b1 0.6 sec\u22121<\/jats:sup> in the control and 13.4 \u00b1 1.5 sec\u22121<\/jats:sup> in the mixture; R<\/jats:italic>2<\/jats:sub> was 6.4 \u00b1 1.1 sec\u22121<\/jats:sup> and 9.8 \u00b1 2.4 sec\u22121<\/jats:sup>, respectively. Thus, the relaxivity effects were enhanced by sequestration of the dysprosium within intact red cells, and this effect was lost after lysis. At a circulating whole\u2010blood concentration of 0.81 \u00b1 0.15 mM in rats, the liver signal intensity dropped 29.9% \u00b1 3.7% and kidney signal intensity dropped 19.4% \u00b1 8.7%. Dysprosium\u2010loaded cells might be useful in the study of perfusion and tissue blood volume. Magn Reson Med 45:920\u2013923, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1122","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T22:53:09Z","timestamp":1031698389000},"page":"920-923","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dysprosium\u2010bearing red cells as potential transverse relaxation agents for MRI"],"prefix":"10.1002","volume":"45","author":[{"given":"Kevin M.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing Zang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P.","family":"Kennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Gore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400118"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.9.2663"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3030-5_42"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(84)90003-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0021-9258(19)57367-7","article-title":"The contribution of magnetic susceptibility effects to transmembrane chemical shift differences in the 31P NMR spectra of oxygenated erythrocyte suspensions","volume":"263","author":"Kirk K","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910310103"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199903)41:3<499::AID-MRM12>3.0.CO;2-O"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.1122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.1122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T20:33:40Z","timestamp":1696797220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.1122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,16]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1002\/mrm.1122"],"URL":"https:\/\/doi.org\/10.1002\/mrm.1122","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,16]]},"assertion":[{"value":"1999-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}