{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:30:26Z","timestamp":1792510226841,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,7,2]],"date-time":"2001-07-02T00:00:00Z","timestamp":994032000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin\u2010labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), or a barbiturate (pentobarbital) using doses commonly employed in experimental paradigms. CBF values were found to be about 2.5\u20133 times lower in most regions analyzed during anesthesia with either fentanyl (with N<jats:sub>2<\/jats:sub>O\/O<jats:sub>2<\/jats:sub>) or pentobarbital vs. isoflurane (with N<jats:sub>2<\/jats:sub>O\/O<jats:sub>2<\/jats:sub>), in agreement with findings utilizing invasive measurement techniques. CBF was heterogeneous in rats anesthetized with isoflurane (with N<jats:sub>2<\/jats:sub>O\/O<jats:sub>2<\/jats:sub>), but relatively homogeneous in rats anesthetized with either fentanyl (with N<jats:sub>2<\/jats:sub>O\/O<jats:sub>2<\/jats:sub>) or pentobarbital, also in agreement with studies using other techniques. Magn Reson Med 46:202\u2013206, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1178","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:59:21Z","timestamp":1030312761000},"page":"202-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin\u2010labeled MRI"],"prefix":"10.1002","volume":"46","author":[{"given":"Kristy S.","family":"Hendrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Kochanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Melick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne 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