{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:03:46Z","timestamp":1760979826782},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,10,18]],"date-time":"2001-10-18T00:00:00Z","timestamp":1003363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010exercise recovery of intracellular pH (pH<jats:sub>i<\/jats:sub>) assessed using phosphorus magnetic resonance spectroscopy has not been previously evaluated in its entirety due to its complex time\u2010course and missing data points resulting from a transient loss of inorganic phosphate signal. By considering the transition from exercise to recovery as a step function input, pH<jats:sub>i<\/jats:sub> recovery was modeled based on the creatine\u2010kinase equilibrium, and the entire pH<jats:sub>i<\/jats:sub> recovery was characterized by calculating the time required for pH<jats:sub>i<\/jats:sub> recovery (<jats:italic>t<\/jats:italic><jats:sub>pHrec<\/jats:sub>). Applying this methodology, normal subjects showed a strong linear correlation between phosphocreatine (PCr) half\u2010time and <jats:italic>t<\/jats:italic><jats:sub>pHrec<\/jats:sub> (<jats:italic>r<\/jats:italic> = 0.90, <jats:italic>P<\/jats:italic> &lt; 0.001). In mitochondrial myopathy (MM) patients with weakness in the limb examined, 9\/10 had faster pH<jats:sub>i<\/jats:sub> recovery relative to PCr recovery; wide normal ranges from a control group which included deconditioned subjects resulted in 7 of those 10 patients having otherwise normal recovery indices. Therefore, modeling pH<jats:sub>i<\/jats:sub> recovery allows characterization of the entire pH<jats:sub>i<\/jats:sub> recovery and detects altered proton handling in MM patients, including those with otherwise normal recovery indices. Magn Reson Med 46:870\u2013878, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1271","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T20:21:44Z","timestamp":1098994904000},"page":"870-878","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Modeling in vivo recovery of intracellular pH in muscle to provide a novel index of proton handling: Application to the diagnosis of mitochondrial myopathy"],"prefix":"10.1002","volume":"46","author":[{"given":"J.T.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Taivassalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Argov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.L.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,18]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180205"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940060504"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90073-6"},{"key":"e_1_2_9_5_2","doi-asserted-by":"crossref","first-page":"7276","DOI":"10.1016\/S0021-9258(19)43389-9","article-title":"Determination of intracellular pH by 31P magnetic resonance","volume":"218","author":"Moon RB","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940060112"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14055.x"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90326-T"},{"key":"e_1_2_9_9_2","first-page":"1","article-title":"Intracellular pH and energy metabolism in skeletal muscle of man with special reference to exercise","volume":"455","author":"Sahlin K","year":"1978","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050276"},{"key":"e_1_2_9_11_2","first-page":"22","article-title":"Bioenergetics of intact human muscle. 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