{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:19:05Z","timestamp":1758478745755},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":6896,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of various calcium antagonists on the ATP, PCr, and <jats:italic>P<jats:sub>i<\/jats:sub><\/jats:italic> levels as well as intracellular pH in normal and ischemic rat brain were examined by 31P NMR spectroscopy using a surface coil. None of the calcium antagonists tested showed any effect in the nonischemic rat brain. However, when global ischemia was induced by cardiac arrest, the ensuring rapid decrease of ATP and PCr and concomitant increase of <jats:italic>p<\/jats:italic><jats:sub>i<\/jats:sub> were significantly retarded by dihydropyridine calcium antagonists, but not by verapamil. The fall in pH caused by ischemia was not affected by either drug. Barbiturates showed effects similar to calcium antagonists, whereas calcium agonists showed the opposite. These results suggest that dihydropyridine calcium antagonists, similar to barbiturates, decrease the high\u2010energy phosphate consumption of the brain, which might be beneficial in instances where their production is severely hampered, e.g., during ischemia. \u00a9 1987 Academic Press, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910040102","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T06:37:13Z","timestamp":1173076633000},"page":"1-8","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effects of calcium antagonists on high\u2010energy phosphates in ischemic rat brain measured by <sup>31<\/sup>P NMR spectroscopy"],"prefix":"10.1002","volume":"4","author":[{"given":"Andr\u00e9","family":"Sauter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Rudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)51740-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10665.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1982.30"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.60.5.0883"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/283167a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1982.31"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1542\/peds.70.2.310","volume":"70","author":"Delpy D. T.","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.9.2748"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb07567.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1981.34"},{"key":"e_1_2_1_12_2","first-page":"3","volume-title":"Proceedings of the 10th Salzburg Conference on Cerebral Vascular Disease","author":"Hass W.","year":"1981"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728881"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90010-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7444460"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/4.suppl_C.109"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1977.tb10394.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(83)90108-7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(84)90109-4"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2120365"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198205000-00003"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198405000-00005"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(82)90223-5"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.33.19"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)91050-6"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80212-9"},{"key":"e_1_2_1_27_2","first-page":"339","volume-title":"Pharmacological Bases of Therapeutics","author":"Harvey S. C.","year":"1975"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1978.tb06279.x"},{"key":"e_1_2_1_29_2","unstructured":"A.Sauter in preparation."},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.52"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1985.tb09448.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/57.1.96"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/57.1.82"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.1910040102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.1910040102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:26:47Z","timestamp":1697880407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.1910040102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/mrm.1910040102"],"URL":"https:\/\/doi.org\/10.1002\/mrm.1910040102","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]},"assertion":[{"value":"1985-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}