{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:40:15Z","timestamp":1760982015879},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":6349,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prior<jats:italic>in vitro<\/jats:italic>studies, utilizing<jats:sup>31<\/jats:sup>P nuclear magnetic resonance (<jats:sup>31<\/jats:sup>P NMR) to measure the chemical shift (\u03c3) of \u03b2\u2010ATP and lengthening of the phosphocreatine spin\u2010spin (<jats:italic>T<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub>) relaxation time, suggested an assessment of their efficacy in measuring magnesium depletion<jats:italic>in vivo.<\/jats:italic>Dietary magnesium depletion (M<jats:sup>2+\u2193<\/jats:sup>) produced markedly lower magnesium in plasma (0.44 vs 1.13 mmol\/liter) and bone (130 vs 190 \u03bcmol\/g) but much smaller changes in muscle (41 vs 45<jats:italic>\u03bcmol\/g, P<\/jats:italic>0.01), heart (42.5 vs 44.6 \u03bcmol\/g), and brain (30 vs 32 \u03bcmol\/g). NMR experiments in anesthetized rats in a Bruker 7\u2010T vertical bore magnet showed that in Mg<jats:sup>2+\u2193<\/jats:sup>rats there was a significant change in brain \u03b2\u2010ATP shift (16.15 vs 16.03 ppm,<jats:italic>P<\/jats:italic>&lt; 0.05). These chemical shifts gave a calculated free [Mg<jats:sup>2+<\/jats:sup>] of 0.71 m<jats:italic>M<\/jats:italic>(control) and 0.48<jats:italic>mM<\/jats:italic>(Mg<jats:sup>2+\u2193<\/jats:sup>). In muscle the change in \u03b2\u2010ATP shift was not significant (Mg<jats:sup>2+\u2193<\/jats:sup>15.99 ppm, controls 15.96 ppm), corresponding to a calculated free MP of 0.83 and 0.95<jats:italic>mM<\/jats:italic>, respectively. Phosphocreatine<jats:italic>T<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub>(Carr\u2010Purcell, spin\u2010echo pulse sequence) was no different with M<jats:sup>2+\u2193<\/jats:sup>in muscle<jats:italic>in vivo<\/jats:italic>(surface coil) (Mg<jats:sup>2+\u2193<\/jats:sup>136, control 142 ms) or in isolated perfused hearts (Helmholtz coil) (control 83, Mg<jats:sup>2+\u2193<\/jats:sup>92 ms).<jats:sup>31<\/jats:sup>P NMR is severely limited in its ability to detect dietary magnesium depletion<jats:italic>in vivo.<\/jats:italic>Measurement of \u03b2\u2010ATP shift in brain may allow studies of the effects of interaction in group studies hut does not allow prediction of an individual magnesium status. \u00a9 1988 Academic Press, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910070307","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T07:12:34Z","timestamp":1173078754000},"page":"300-310","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Problems in the assessment of magnesium depletion in the rat by<i>in vivo<\/i><sup>31<\/sup>P NMR"],"prefix":"10.1002","volume":"7","author":[{"given":"William R.","family":"Adam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Craik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon G.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malea M.","family":"Kneen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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