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It was used to enhance the accuracy of <jats:sup>31<\/jats:sup>P NMR data in the diagnosis of myopathies. DFA allowed a good separation of normal subjects, congenital neuromuscular disorders with type I fiber predominance, and McArdle's diseases. It elicited an unexpected homogeneity of idiopathic rhabdomyolyses, the metabolic origin of which is unknown, and suggested that the abnormality could involve the mitochondrial oxidative metabolism in some of them. In mitochondrial myopathies, an expected heterogeneity is shown by DFA. It may allow an automatic diagnosis of some myopathies from <jats:sup>31<\/jats:sup>P NMR data or guide biochemists by comparing biochemical features of a new patient to those of previously established groups.<\/jats:p>","DOI":"10.1002\/mrm.1910130205","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T10:35:28Z","timestamp":1173090928000},"page":"216-227","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Discriminant factor analysis of <sup>31<\/sup>p nmr spectroscopic data in myopathies"],"prefix":"10.1002","volume":"13","author":[{"given":"D.","family":"Morvan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Jehenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Duboc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Syrota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Intracellular pH, Its Measurement, Regulation and Utilization in Cellular Functions","author":"Gadian D. 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