{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:22:43Z","timestamp":1761128563023},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":5619,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1990,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The currently favored theory of pathogenesis of malignant hyperthermia (MH) implicates an abnormality in skeletal muscle calcium ion transport. During a MH crisis a profound lactic acidosis occurs and in MH\u2010sensitive individuals a delayed recovery of venous lactate has been previously noted postexercise. We have used <jats:sup>31<\/jats:sup>P magnetic resonance spectroscopy to follow noninvasively <jats:italic>in vivo<\/jats:italic> changes in muscle of intracellular pH and high\u2010energy phosphate metabolites during rest, exercise, and recovery of MH\u2010sensitive subjects. Eleven biopsy\u2010positive MH\u2010sensitive patients have been studied and compared to 26 normal subjects. The MH\u2010sensitive subjects as a group prematurely dropped their intracellular pH during mild aerobic exercise and they demonstrated a marked delay before the recovery of pH after maximal exercise. PCr\/(PCr + <jats:italic>P<\/jats:italic><jats:sub><jats:italic>i<\/jats:italic><\/jats:sub>) ratios also dropped early during exercise but recovered normally. The observed changes in pH and PCr\/(PCr + <jats:italic>P<\/jats:italic><jats:sub><jats:italic>i<\/jats:italic><\/jats:sub>) are consistent with a myopathy in MH\u2010susceptible individuals. \u00a9 1990 Academic Press, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910150109","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T11:22:24Z","timestamp":1173093744000},"page":"81-89","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Metabolic response to exercise in malignant hyperthermia\u2010sensitive patients measured by <sup>31<\/sup>P magnetic resonance spectroscopy"],"prefix":"10.1002","volume":"15","author":[{"given":"D. W.","family":"Webster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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