{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:48:27Z","timestamp":1760014107741},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":5588,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnetic resonance (MR) imaging, localized<jats:italic>in vivo<\/jats:italic>proton spectroscopy, and<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>relaxation measurements were obtained from the livers of rats treated chronically with carbon tetrachloride and phospholipase D. The MR data correlated well with lipid changes measured biochemically and histologically. MR images appeared generally hyperintense during fatty infiltration, changing to hypointense mottling during cirrhosis. Water<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>relaxation times showed no statistically significant change at any time during the experiments from the control value of 908 ms (SE = 42 ms). Minor changes in lipid<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>values with time were noted. The average lipid<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>curve demonstrated a linear relation with time (<jats:italic>r<\/jats:italic>= 0.81), increasing from the control value of 283 ms (\u00b116 ms) to 365 ms (\u00b153 ms) at the end of the third week and decreasing slightly through the end of the experiment. Water\u2010suppressed<jats:italic>in vivo<\/jats:italic>spectra showed quantitative changes in liver lipids which correlated well with the biochemical and histologic analysis. From the MR images and spectroscopy results it was possible to distinguish early fatty liver from more advanced cirrhosis. \u00a9 1990 Academic Press, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910150205","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T11:15:11Z","timestamp":1173093311000},"page":"211-228","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Chronic carbon tetrachloride and phospholipase D hepatotoxicity in rat:<i>In vivo<\/i><sup>1<\/sup>H magnetic resonance, total lipid analysis, and histology"],"prefix":"10.1002","volume":"15","author":[{"given":"John D.","family":"Hazle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponnada A.","family":"Narayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold A.","family":"Dunsford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Pathophysiology of the Liver","author":"Albano E.","year":"1988"},{"key":"e_1_2_1_3_2","volume-title":"Biochemical Mechanisms of Liver Injury","author":"Dianzani M. 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