{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:59:25Z","timestamp":1760345965747},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":5404,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soluble and insoluble polysaccharides were derivatized with diethylenetriaminepentaacetic acid (DTPA) and\/or spin\u2010labeled with 2,2,6,6\u2010tetramethylpiperidine\u20101\u2010oxyl (TEMPO). Polysaccharides derivatized with DTPA were prepared via cyanogen bromide activation, coupling to a diamine linker, and to DTPA anhydride. Spin\u2010labeled polysaccharides were also prepared via cyanogen bromide activation. The extent of derivatization for dextran (18 kDa) was about 120 glucose units per DTPA, and for cellulose and starch about 15\u201330 units per DTPA. For spin\u2010labeled polysaccharides, the average loading ranged from 1 nitroxide per 16 glucose units for starch to 181 for dextran (82 kDa). These derivatized paramagnetic polysaccharides were shown to be more effective relaxants than the small paramagnetic molecules alone. Both soluble and insoluble polysaccharide\u2010linker\u2010DTPA\u2010Gd(III) complexes were effectively cleared from the body (rats) after oral administration. After intravenous administration, the biodistribution of dextran\u2010linker\u2010DTPA\u2010Gd(III) complexes differed significantly from that of GdDTPA. Reduction of the nitroxide by ascorbic acid was retarded in the polysaccharide derivatives, particularly in starch enrivatized with both nitroxide and linker\u2010DTPA\u2010Cu(II). These agents showed contrast enhancement in the gastrointestinal tract of rabbits. \u00a9 1991 Academic Press, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910170222","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T12:24:00Z","timestamp":1173097440000},"page":"516-532","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Use of Paramagnetic Chelated Metal Derivatives of Polysaccharides and Spin\u2010Labeled Polysaccharides as Contrast Agents in Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"17","author":[{"given":"S. W. A.","family":"Bligh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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