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The acidotic brain pH seen in the acute stage of infarction was observed to rebound into the alkalotic range in the subacute phase before returning to the normal range in the chronic phase. This \u201crebound alkalosis\u201d which was usually observed between the 24th and the 48th hour after experimental induction of infarction in rats was accompanied by significant lactate levels as detected by proton NMR spectroscopy. Analysis of the satellite methyl resonance of <jats:sup>13<\/jats:sup>C\u2010lactate using high\u2010resolution proton NMR spectroscopy after <jats:sup>13<\/jats:sup>C\u2010glucose infusion indicated that no lactate was produced in the subacute phase of infarction and that the lactate detected during this phase must have been generated prior to this phase of infarction. \u00a9 1991 Academic Press. Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910180103","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T12:23:47Z","timestamp":1173097427000},"page":"9-14","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Rebound alkalosis and persistent lactate: Multinuclear (<sup>1<\/sup>H, <sup>13<\/sup>C, <sup>31<\/sup>P) NMR spectroscopic studies in rats"],"prefix":"10.1002","volume":"18","author":[{"given":"Tsutomu","family":"Nakada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohiro","family":"Houkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Hida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid L.","family":"Kwee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb03396.x"},{"key":"e_1_2_1_3_2","volume-title":"Lactic Acidosis in the Brain","author":"Siesj\u00f3 B. 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