{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:40:45Z","timestamp":1698126045411},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":5376,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This small experimental study describes the effects on the NMR relaxation times in normal cat brain of a 5\u2010day course of high dose methylprednisolone and, separately, a 1\u2010month course of standard dose daily chlorpromazine. Methylprednisolone had no influence on <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> or <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> in these tissues, but chlorpromazine produced a transient fall of <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> of thalamus, and rise in <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> of white matter: both normalize after 4 weeks. The mechanism of these changes is unknown. It is concluded that these drugs should not interfere with the quantitative MRI monitoring of brain abnormalities in patients receiving them, although the unlikely occurrence of longer term effects of chlorpromazine has not been excluded. \u00a9 1991 Academic Press. 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