{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:59:53Z","timestamp":1788994793512,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":5101,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This review reports data on the general and renal tolerance of the paramagnetic contrast agent Gd\u2010DTPA after intravenous administration. Gd\u2010DTPA was administered usually at a dose level of 0.1\u20100.2 mmol\/kg body wt (range: 0.005\u20100.25 mmol\/kg body wt) in cranial, spinal and body MR indications. In phase I\u2010IIIa studies a total of 2154 healthy volunteers and patients were investigated, usually at a dose of 0.1 mmol\/kg body wt. From the obtained results it was concluded that adverse events (AEs) may be expected in the order of magnitude of 1%. In phase IIIb\u2010IV studies 13,439 patients were investigated at 0.1 or 0.2 mmol\/kg body wt. Tolerance data were collected according to a standardized protocol and metaanalysis of obtained data was performed. AEs, irrespective of their drug relationship, were observed in 1.15% of the patients. The observed AEs were comparable to those after intravenous administration of iodinated nonionic X\u2010ray contrast media. There was no correlation between patient age and the incidence of AEs. In patients with a known history of allergy the incidence of AEs increased to 2.6%. In pediatric use no added risk was observed in a total of 826 neonates, children, and adolescents up to 18 years of age. Gd\u2010DTPA showed good renal tolerance in patients with and without preexisting impairment of renal function. A prospective open safety and pharmacokinetic study was conducted in patients with hemodialysis. Gd\u2010DTPA was shown to be eliminated completely by hemodialysis. Fast bolus injections were tolerated without added risk. Presented data from postmarketing surveillance (up to March 31, 1991) cover an estimated total of more than 2,000,000 applications. In conclusion, Gd\u2010DTPA showed an excellent safety profile after intravenous administration of diagnostic doses to patients of all age groups, irrespective of the injection speed and preexisting renal impairment. The overall incidence of AEs after intravenous injection of 0.1 or 0.2 mmol Gd\u2010DTPA\/kg body wt was found to be 1\u20132%. \u00a9 1991 Academic Press, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910220212","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T08:22:12Z","timestamp":1173082932000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Safety of gadolinium\u2010DTPA: Extended clinical experience"],"prefix":"10.1002","volume":"22","author":[{"given":"H. 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