{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T17:27:13Z","timestamp":1708795633453},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":5101,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A transient alkalosis of similar magnitude to that observed <jats:italic>in vivo<\/jats:italic> has been observed using <jats:sup>31<\/jats:sup>P NMR and 2\u2010deoxy\u2010D\u2010glucose\u20106\u2010phosphate as a pH marker in a human glioma cell line, SKI\u20101, with demonstrated sensitivity to 1, 3\u2010bis (2\u2010chloroethyl)\u20101\u2010nitrosourea. At an effective dose of 5 \u00b1 1 \u00d7 10 \u03bcg\/ml, an increase of 0.13 \u00b1 0.05 pH units was observed within 4 \u00b1 1 \u00d7 10 min of introducing the drug into the perfusion chamber. Although the <jats:italic>in vitro<\/jats:italic> response is of a time course much faster than that <jats:italic>in vivo<\/jats:italic>, these results suggest that this immediate pH change could be an indicator of the cytotoxic action of the drug. \u00a9 1991 Academic Press, Inc.<\/jats:p>","DOI":"10.1002\/mrm.1910220247","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T13:22:12Z","timestamp":1173100932000},"page":"394-403","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alkalosis monitored by <sup>31<\/sup>P NMR in a human glioma cell line exposed to the anti\u2010tumor drug 1, 3\u2010bis (2\u2010chloroethyl)\u20101\u2010nitrosourea"],"prefix":"10.1002","volume":"22","author":[{"given":"Fernando","family":"Commodari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan C.","family":"Sanctuary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Feindel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Shoubridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-565060-1.50005-5"},{"key":"e_1_2_1_3_2","first-page":"263","volume":"54","author":"Walker M. D.","year":"1970","journal-title":"Cancer Chemother. Rep."},{"key":"e_1_2_1_4_2","first-page":"992","volume":"42","author":"Yung W. A.","year":"1982","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165183"},{"key":"e_1_2_1_6_2","first-page":"175","volume":"43","author":"Aukerman S. L.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00339a010"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00325a011"},{"key":"e_1_2_1_9_2","first-page":"351","volume":"2","author":"Eisenbrand G.","year":"1988","journal-title":"Anti\u2010Cancer Drug Design"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00181a018"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/4.6.759"},{"key":"e_1_2_1_12_2","first-page":"3736","volume":"44","author":"Bodell W. J.","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90027-X"},{"key":"e_1_2_1_14_2","first-page":"570","volume":"14","author":"Arnold D. L.","year":"1987","journal-title":"Can. J. Neurol. Sci."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198912000-00007"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1960171"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00257311"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(84)90176-9"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00316a033"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00295a008"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"11,032","DOI":"10.1016\/S0021-9258(18)60922-6","volume":"262","author":"Defronzo M.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(88)83084-4"},{"key":"e_1_2_1_23_2","unstructured":"C.DeutschandJ.Taylor inpp.33\u201347"},{"key":"e_1_2_1_23_3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb32892.x"},{"key":"e_1_2_1_24_2","first-page":"65","volume":"6","author":"Demetrokopoulos G. E.","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb08560.x"},{"key":"e_1_2_1_26_2","unstructured":"J. J. H.Ackerman \u201cCerbral Deoxyglucose Metabolism:13C19F31P Surface Coil NMR Spectroscopy of Rat Brainin vivo \u201d SMRM Abstracts pp.77 Amsterdam 1989."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)81010-6"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0584-8539(88)80130-2"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81246-3"},{"key":"e_1_2_1_30_2","first-page":"544","volume":"50","author":"Kaplan O.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0021-9258(18)70358-X","volume":"234","author":"Kipnis D. M.","year":"1959","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1988.255.2.C192"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165608"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.1910220247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.1910220247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T23:35:11Z","timestamp":1698017711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.1910220247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1002\/mrm.1910220247"],"URL":"https:\/\/doi.org\/10.1002\/mrm.1910220247","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]},"assertion":[{"value":"1989-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}