{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:47:37Z","timestamp":1757702857355},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":4966,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the conclusion of this series of reports, the application of <jats:sup>31<\/jats:sup>P\/<jats:sup>2<\/jats:sup>H NMR to investigate the pathophysiology of sepsis in rat hindlimb muscle is demonstrated. Sepsis decreased muscle [PCr] by 18%, 18 \u00b1 4 SD vs 22 \u00b1 4 SD mmol\/kg tissue wet wt (<jats:italic>P<\/jats:italic> = 0.01) in control rats but [ATP] was unchanged, 6 mmol\/kg tissue wet wt (<jats:italic>P<\/jats:italic> = 0.2). The derived free cytosolic [ADP] in the two groups was similar, [ADP]<jats:sub>septic<\/jats:sub> = 0.023 \u00b1 0.004 SD and [ADP]<jats:sub>control<\/jats:sub>, = 0.021 \u00b1 0.003 SD mmol\/kg tissue wet wt, and not statistically different <jats:italic>(P<\/jats:italic> =0.14). Likewise [P<jats:sub>i<\/jats:sub>] in the septic and control groups was not statistically different, [P<jats:sup>i<\/jats:sup>]<jats:sub>septic<\/jats:sub> = 1.1 \u00b1 0.5 SD and [P<jats:sub>i<\/jats:sub>]<jats:sub>control<\/jats:sub>, = 1.2 \u00b1 0.4 SD mmol\/kg tissue wet wt (<jats:italic>P<\/jats:italic> = 0.2). Septic rats presented the symptom of respiratory alkalosis evidenced by elevated blood pH. Sepsis decreased muscle blood flow by 33%, <jats:italic>P<\/jats:italic> = 0.003, but examination of individual subjects did not demonstrate a correlation with the reduction in [PCr]. Thus, a metabolic energy deficit caused by cellular ischemia\/hypoxia is not a likely cause of cellular abnormality in rat hindlimb muscle during sepsis.<\/jats:p>","DOI":"10.1002\/mrm.1910250107","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T13:44:28Z","timestamp":1173102268000},"page":"67-77","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Concurrent quantification of tissue metabolism and blood flow via <sup>2<\/sup>h\/<sup>31<\/sup>P NMR <i>in Viva<\/i> iii. alterations of muscle blood flow and metabolism during sepsis"],"prefix":"10.1002","volume":"25","author":[{"given":"Sheng\u2010Kwei","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Hotchkiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene E.","family":"Karl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J. 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