{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:40:19Z","timestamp":1760982019871},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":4029,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral <jats:italic>in vivo<\/jats:italic> proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan\u20101,2\u2010diol (the injection vehicle for both these anticonvulsants). Subsequent <jats:italic>in vitro<\/jats:italic> spectroscopy of cerebro spinal fluid (CSF) from one of these infants also showed signals from this substance. The estimated <jats:italic>in vivo<\/jats:italic> propan\u20101,2\u2010diol concentration (\u223c3 m<jats:italic>M<\/jats:italic>) was less than that measured in the CSF sample (14.4 m<jats:italic>M<\/jats:italic>). These observations suggest that propan\u20101,2\u2010diol may accumulate in cerebral tissue and misidentification of its signals in both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> proton spectra may confuse diagnoses of metabolic or other disorders.<\/jats:p>","DOI":"10.1002\/mrm.1910320611","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T18:56:58Z","timestamp":1173121018000},"page":"764-767","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Detection of propan\u20101,2\u2010diol in neonatal brain by <i>in vivo<\/i> proton magnetic resonance spectroscopy"],"prefix":"10.1002","volume":"32","author":[{"given":"Ernest B.","family":"Cady","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Lorek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet","family":"Penrice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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