{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:43:21Z","timestamp":1777434201678,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":3943,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Longitudinal (<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>) and apparent transverse relaxation times (<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>) of choline\u2010containing compounds (Cho), creatine\/phospho\u2010creatine (Cr\/PCr), and N\u2010acetyl aspartate (NAA) were measured <jats:italic>in vivo<\/jats:italic> in human brain at 4 Tesla. Measurements were performed using a water suppressed stimulated echo pulse sequence with complete outside volume presaturation to improve volume localization at short echo times. <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010values of Cho (1.2 \u00b1 0.1 s), Cr (1.6 \u00b1 0.3 s), and NAA (1.6 \u00b1 0.2 s) at 4 Tesla in occipital brain were only slightly larger than those reported in the literature at 1.5 Tesla. Thus, TR will not adversely affect the expected enhancement of signal\u2010to\u2010noise at 4 Tesla. Surprisingly, apparent <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010values of Cho (142 \u00b1 34 ms), Cr (140 \u00b1 13 ms), and NAA (185 \u00b1 24 ms) at 4 Tesla were significantly smaller than those at 1.5 Tesla and further decreased when increasing the mixing interval TM. Potential contributing factors, such as diffusion in local susceptibility related gradients, dipolar relaxation due to intracellular paramagnetic substances and motion effects are discussed. The results suggest that short echo time spectroscopy is advantageous to maintain signal to noise at 4 Tesla.<\/jats:p>","DOI":"10.1002\/mrm.1910330215","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T18:39:30Z","timestamp":1173119970000},"page":"246-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Anomalous Transverse Relaxation in <sup>1<\/sup>H Spectroscopy in Human Brain at 4 Tesla"],"prefix":"10.1002","volume":"33","author":[{"given":"Stefan","family":"Posse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Andre","family":"Cuenod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Risinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis Le","family":"Bihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Balaban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910070405"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.6.1821"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910110105"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910150212"},{"key":"e_1_2_1_6_2","unstructured":"P. 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