{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:39:21Z","timestamp":1762375161327},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":3854,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>N<\/jats:italic>\u2010acetylaspartate (NAA) has previously been proposed as a neuronal marker. <jats:sup>1<\/jats:sup>H magnetic resonance spectroscopy (MRS) is able to detect NAA in brain, and decreases of NAA have been documented after brain injury. The reason for this decrease is not fully understood and neuron loss damage and \u201cdysfunction\u201d have all been proposed. It is hypothesized that acute central nervous system (CNS) deafferentation causes a trans\u2010synaptic NAA decrease and that high resolution <jats:sup>1<\/jats:sup>H MRS is able to detect such a decrease. To test this hypothesis, an experimental model was used in which axonal lesions were obtained by stretch injury in guinea pig right optic nerve (95\u201399% crossed fibers). The trans\u2010synaptic concentration of NAA, total creatine (Cr), and the NAA\/Cr ratio in lateral geniculate bodies (LGB) and superior colliculi (SC) sample extracts were measured 72 h later by high resolution <jats:sup>1<\/jats:sup>H MRS. In the left LGB\/SC, which is where right optic nerve fibers project, reductions of NAA and NAA\/Cr were found whereas Cr levels were normal. NAA, NAA\/Cr, and Cr values were all normal in the right LGB\/SC. Histology and EM findings revealed no abnormalities. At 7 days, left LGB\/SC NAA and NAA\/Cr values were in the normal range. It was concluded that 1) acute deafferentation in the CNS causes a trans\u2010synaptic decrease of NAA levels that can be detected by <jats:sup>1<\/jats:sup>H MRS and 2) NAA decrease may be due to changes of NAA metabolism caused by functional neuronal inactivity rather than neuronal loss, injury or \u201cdysfunction.\u201d <jats:sup>1<\/jats:sup>H MRS is a potential tool for the study of functional effect of CNS lesions <jats:italic>in vivo.<\/jats:italic><\/jats:p>","DOI":"10.1002\/mrm.1910330503","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T18:29:39Z","timestamp":1173119379000},"page":"595-600","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Central nervous system trans\u2010synaptic effects of acute axonal injury: a <sup>1<\/sup>h magnetic resonance spectroscopy study"],"prefix":"10.1002","volume":"33","author":[{"given":"Mario","family":"Rango","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Spagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giustino","family":"Tomei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizia","family":"Bamonti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Scarlato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Zetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(89)80048-X"},{"key":"e_1_2_1_3_2","unstructured":"P.Arnold Reversible reduction ofN\u2010acetylaspartate after acute central nerouus system damage in \u201cProc. SMRM 11th Annual Meeting Berlin 1992 \u201d p.643."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.8.1578"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb12854.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1966.tb05872.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1969.tb05993.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb01665.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.48"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290605"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.11.1042"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.74"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00340846"},{"key":"e_1_2_1_14_2","first-page":"303","article-title":"Trans\u2010synaptic atrophy in the human lateral geniculate nucleus following unilateral enucleation","volume":"21","author":"Kupfer C.","year":"1962","journal-title":"Fed. 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Neurol."},{"key":"e_1_2_1_21_2","first-page":"153","article-title":"Transneuronal degeneration in the human inferior olive: an immuno histochemical study","volume":"42","author":"Barron K.","year":"1992","journal-title":"Neurology"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.1910330503","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.1910330503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T16:31:43Z","timestamp":1698337903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.1910330503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["10.1002\/mrm.1910330503"],"URL":"https:\/\/doi.org\/10.1002\/mrm.1910330503","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5]]},"assertion":[{"value":"1994-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}