{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T08:36:51Z","timestamp":1725698211900},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":3823,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors present a high field <jats:italic>in vivo<\/jats:italic> demonstration of our 2\u2010dimensional calibration methods for determining magnesium ion concentration ([Mg]), under conditions of fluctuating pH, from the three <jats:sup>31<\/jats:sup>P NMR chemical shift differences of ATP. The effect of 3 h of hypoxic\u2010ischemic insult (HI) on intracellular brain [Mg] was evaluated by using a well established 7\u2010day\u2010old rat model of cerebral HI. During the final hour of HI, there was a significant increase (<jats:italic>P<\/jats:italic> &lt; 0.001) in free magnesium as well as in the ratio of total [Mg]\/[ATP]. The normal, HI, and early (1\u20132 h) recovery values of free [Mg] were 0.336 \u00b1 0.015, 0.519 \u00b1 0.104, and 0.337 \u00b1 0.071 mM, respectively. These results are consistent with the temporal changes in [ATP]. Our assessment of [Mg] and pH for this high error measurement is general for most <jats:italic>in vivo<\/jats:italic> applications and may be routinely implemented.<\/jats:p>","DOI":"10.1002\/mrm.1910330618","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T18:28:03Z","timestamp":1173119283000},"page":"853-857","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Application of the Accurate Assessment of Intracellular Magnesium and pH from the <sup>31<\/sup>P Shifts of ATP to Cerebral Hypoxia\u2010Ischemia in Neonatal Rat"],"prefix":"10.1002","volume":"33","author":[{"given":"Gerald D.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198811000-00012"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.53.030191.001421"},{"key":"e_1_2_1_4_2","first-page":"1","article-title":"Magnesium and brain trauma","volume":"10","author":"Vink R.","year":"1991","journal-title":"Magnes. 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SMR 2nd Annual Meeting San Francisco 1994 \u201d p.1271."},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6810"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.1910330618","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.1910330618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T17:44:01Z","timestamp":1698255841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.1910330618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1002\/mrm.1910330618"],"URL":"https:\/\/doi.org\/10.1002\/mrm.1910330618","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]},"assertion":[{"value":"1994-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}