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Male Sprague\u2010Dawley rats (<jats:italic>n<\/jats:italic> = 29) were deprived of thiamine via a regimen of thiamine\u2010deficient chow and daily intraperitoneal injections of the thiamine antagonist pyrithiamine hydrobromide. Spectra were obtained by using the STEAM sequence. No significant change occurred in the ratio of Cr\/NAA, while the ratio of Cho\/NAA declined significantly (60 \u00b1 11%) on Day 14. Eleven rats received intraperitoneal injections of thiamine hydrochloride at the end of 12 days, and dose\u2010dependent recovery in Cho\/NAA was observed.<\/jats:p>","DOI":"10.1002\/mrm.1910340306","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T19:25:46Z","timestamp":1173122746000},"page":"313-318","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>In Vivo<\/i> localized proton NMR spectroscopy of thiamine\u2010deficient rat brain"],"prefix":"10.1002","volume":"34","author":[{"given":"Haakil","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Tarter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Holburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald R.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb05668.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00718.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199111000-00034"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072888"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3975622"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(90)90038-E"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03635.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1523\/JNEUROSCI.10-05-01664.1990","article-title":"Protective effects of the glutamate antagonist MK\u2010801 on pyrithiamine\u2010induced lesions and amino acid changes in the rat brain","volume":"10","author":"Langlais P. 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