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Using normal and blood flow restricted gastrocnemius muscles it was shown that the decrease of the EPR signals of the nitroxides in tissues was due principally to perfusion, which redistributed the nitroxides. Changes in pO<jats:sub>2<\/jats:sub> were reflected by changes of the linewidth; only a perdeuterated nttroxide with a narrow line was an adequate indicator for this parameter. This technique was applied experimental murine tumors (MTG\u2010B and RIF\u20101) to determine the perfusion and pO<jats:sub>2<\/jats:sub> in these relatively hypoxic model tumor systems. Using the paramagnetic properties of the nitroxides to enhance T<jats:sub>1<\/jats:sub>\u2010weighted MR images, heterogeneity in perfusion in individual tumors was demonstrated.<\/jats:p>","DOI":"10.1002\/mrm.1910350113","type":"journal-article","created":{"date-parts":[[2007,3,11]],"date-time":"2007-03-11T16:03:54Z","timestamp":1173629034000},"page":"97-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Use of nitroxides for assessing perfusion, oxygenation, and viability of tissues: <i>In vivo<\/i> EPR and MRI studies"],"prefix":"10.1002","volume":"35","author":[{"given":"Bernard","family":"Gallez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Bacic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Goda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"O\u2032Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff F.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold M.","family":"Swartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2307\/3578481"},{"key":"e_1_2_1_3_2","first-page":"121","article-title":"Vascularity, perfusion rate and local tissue oxygenation of tumors derived from ras\u2010transformed fibroblasts","volume":"48","author":"Kallinowski F.","year":"1991","journal-title":"Int."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90851-8"},{"key":"e_1_2_1_5_2","first-page":"6449","article-title":"Blood flow, oxygen, and nutrient supply, and metabolic environment of human tumors: a review","volume":"49","author":"Vaupel P.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_1_6_2","first-page":"261","volume-title":"EPR Imaging and in vivo EPR","author":"Swartz H. 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