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The commonly used nitroxides exhibit multiple lines, causing either hyper\u2010fine\u2010based limitations in the maximum obtainable image resolution or hyperfine\u2010based artifacts in the reconstructed image. The application of a numerical method, based on forward\u2010subtraction principles for removing hyperfine artifacts in the measured projections is reported. It is demonstrated by using computer simulations, imaging of phantoms, and imaging of rat hearts, that marked enhancement in image quality and resolution can be obtained by removing the hyper\u2010fine\u2010imposed limit on the gradient magnitude and performing postacquisition corrections for removing hyperfine artifacts in the image.<\/jats:p>","DOI":"10.1002\/mrm.1910350308","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T14:18:32Z","timestamp":1296742712000},"page":"316-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A forward\u2010subtraction procedure for removing hyperfine artifacts in electron paramagnetic resonance imaging"],"prefix":"10.1002","volume":"35","author":[{"given":"Periannan","family":"Kuppusamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay L.","family":"Zweier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/05704928608060437"},{"key":"e_1_2_1_3_2","first-page":"275","article-title":"ESR imaging","volume":"11","author":"Ohno K.","year":"1987","journal-title":"Magn. 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