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After optimization of the sequence in phantom and volunteer studies, a clinical pilot study with 14 patients was performed. In carcinomas the relative signal increase after Gd\u2010DTPA administration was on average 34% in MT\u2010FLASH images compared with 169% in conventional <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> weighted (T1W) three\u2010dimensional FLASH images. In MT\u2010FLASH images, all lesions demonstrated a signal intensity higher than that of fat; in T1W images, all lesions have a lower signal intensity. The average postcontrast carcinoma\u2010to\u2010fat contrast\u2010to\u2010noise ratios were +11.6 and \u221214.2, respectively. The conspicutty of 12 of 13 carcinomas was improved in postcontrast MT\u2010FLASH images compared with postcontrast T1w images. Thus, MT\u2010FLASH imaging enables excellent visualization of Gd\u2010DTPA\u2010enhancing breast lesions.<\/jats:p>","DOI":"10.1002\/mrm.1910350612","type":"journal-article","created":{"date-parts":[[2007,3,11]],"date-time":"2007-03-11T19:33:56Z","timestamp":1173641636000},"page":"861-869","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Improved visualization of breast lesions with gadolinium\u2010enhanced magnetization transfer MR imaging"],"prefix":"10.1002","volume":"35","author":[{"given":"Wolfgang G.","family":"Schreiber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Brix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.","family":"Knopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"He\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter J.","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.170.3.2916021"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.1.2648479"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.2.2296657"},{"issue":"4","key":"e_1_2_1_5_2","first-page":"545","article-title":"A fast 3D\u2010imaging technique for performing dynamic Gd\u2010enhanced MRI of breast lesions","volume":"12","author":"Perman W. 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