{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:05:25Z","timestamp":1787972725386,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3298,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1996,12]]},"abstract":"Abstract<\/jats:title>In vivo, ex vivo<\/jats:italic>, and in vitro<\/jats:italic> proton magnetic resonance spectroscopy was performed in 12 patients with intracranial tuberculomas with an aim of detecting the biochemical constituents of Mycobacterium tuberculosis<\/jats:italic> in a granuloma. One dimensional (1D) single pulse and spin\u2010echo sequences and 2D correlative spectroscopy were used for the ex vivo<\/jats:italic> study to confirm the resonances seen on in vivo<\/jats:italic> study. Spectroscopic studies of the perchloric acid and lipid extract of granuloma and M. tuberculosis<\/jats:italic> were performed to look for similarity of resonance. In vivo<\/jats:italic> study showed the presence of lipids at 0.9, 1.3, 2.0, 2.8 ppm, and phosphoserine at 3.7 ppm. All these resonances were confirmed on ex vivo<\/jats:italic> study. In addition, distinct resonances of serine and phenolic lipids were seen on ex vivo<\/jats:italic> and in vitro<\/jats:italic> study of tuberculous granuloma, which have not been observed in other intracranial tumors. Lipid extract of granuloma and M. tuberculosis<\/jats:italic> showed phenolic lipids at 7.1 and 7.4 ppm, a constituent of the cell wall of the bacteria in a tuberculoma. It appears that it may be possible to finger print the biochemicals of the cell wall of M. tuberculosis<\/jats:italic> in a tuberculous granuloma and thus may help in detection and diagnosis of such lesions.<\/jats:p>","DOI":"10.1002\/mrm.1910360605","type":"journal-article","created":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T09:44:12Z","timestamp":1173692652000},"page":"829-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Finger printing of mycobacterium tuberculosis in patients with intracranial tuberculomas by using in vivo<\/i>, ex vivo<\/i>, and in vitro<\/i> magnetic resonance spectroscopy"],"prefix":"10.1002","volume":"36","author":[{"given":"Rakesh K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazhar","family":"Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Poptani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janak","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiya P.","family":"Bhaduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/9781555818357.ch3"},{"issue":"4","key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0033-8389(22)00618-2","article-title":"MR imaging of central nervous system tuberculosis","volume":"33","author":"Jinkins J. 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