{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:27:48Z","timestamp":1792081668254,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3024,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The metabolic activation resulting from direct dopaminergic stimulation can be detected using auto\u2010radiography, positron emission tomography (PET) or, potentially, fMRI techniques. To establish the validity of the latter possibility, we have performed a number of experiments. We measured the regional selectivity of two different dopaminergic ligands: the dopamine release compound D\u2010amphetamine and the dopamine transporter antagonist 2\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010fluoropheny) tropane (CFT). Both compounds led to increased signal intensity in gradient echo images in regions of the brain with high dopamine receptor density (frontal cortex, striatum, cingulate cortex \u226b parietal cortex). Lesioning the animals with unilaterally administered 6\u2010hydroxydopamine (6\u2010OHDA) led to ablation of the phMRI response on the ipsilateral side; control measurements of rCBV and rCBF using bolus injections of Gd,\u2010DTPA showed that the baseline rCBV and rCBF values weire intact on the lesioned side. The time course of the BOLD signal changes paralleled the changes observed by microdialyisis measurements of dopamine release in the striatum for both amphetamine and CFT; peaking at 20\u201340 min after injection and returning to baseline at about 70\u201390 min. Signal changes were not correlated with either heart rate, blood pressure or pCO<jats:sub>2<\/jats:sub>. Measurement of PET binding in the same animals showed an excellent correlation with the phMRI data when compared by either measurements of the number of pixels activated or percent signal change in a given region. The time course for the behavioral measurements of rotation in the 6\u2010OHDA lesioned animals correlated with the phMRI. These experiments demonstrate that phMRI will become a valuable, noninvasive tool for investigation of neurotransmitter activity <jats:italic>in vivo<\/jats:italic>. Key words: fMRI; dopamine; amphetamine; CFT.<\/jats:p>","DOI":"10.1002\/mrm.1910380306","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T06:00:59Z","timestamp":1173765659000},"page":"389-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":212,"title":["Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: Correlation with PET, microdialysis, and behavioral data"],"prefix":"10.1002","volume":"38","author":[{"given":"Yin Ching I.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy R.","family":"Galpern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Liisa","family":"Brownell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell T.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Bogdanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Isacson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Keltner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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