{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:32:06Z","timestamp":1791178326272,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":3024,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion\u2010weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuritis and nine nerves with chronic neuritis. The mean ADC (4.18 \u00b1 1.13 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>n<\/jats:italic> = 9) in the optic nerves with chronic neuritis was significantly higher than that in normal volunteers (1.56 \u00b1 0.675 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>n<\/jats:italic> = 14) and that in the nerves with acute neuritis (0.94 \u00b1 0.43 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s <jats:italic>n<\/jats:italic> = 4) (P &lt; 0.001). The ADC is useful in assessing MS foci in the optic nerves.<\/jats:p>","DOI":"10.1002\/mrm.1910380317","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T05:51:25Z","timestamp":1173765085000},"page":"484-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Diffusion\u2010weighted imaging of the human optic nerve: A New approach to evaluate optic neuritis in multiple sclerosis"],"prefix":"10.1002","volume":"38","author":[{"given":"Tae","family":"Iwasawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Matoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Ogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.2.175"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199103000-00006"},{"key":"e_1_2_1_4_2","first-page":"923","article-title":"Contrast\u2010enhaxed MR imaging of optic nerve lesions in patients with acute optic neuritis","volume":"12","author":"Merandi S. 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