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By comparison of spectra from the occipital lobe of patients receiving a homocarnosine elevation drug to normal subjects we have assigned two elevated resonances in the short <jats:italic>TE<\/jats:italic> <jats:sup>1<\/jats:sup>H MRS spectrum to homocarnosine. These resonances are partially resolved at 7.05 and 8.02 ppm in a short <jats:italic>TE<\/jats:italic> spectrum at 2.1 T when macromolecule resonances are removed by subtraction of a spectrum in which the metabolite resonances are nulled by inversion recovery. The chemical shift of both of these resonances is sensitive to pH<jats:sub>i<\/jats:sub>. By comparison with a titration curve the pH<jats:sub>i<\/jats:sub> was calculated from the downfield resonance to be 7.06 in the patient group which is similar to values reported using the P<jats:sub>i<\/jats:sub> resonance. Based on the <jats:italic>in vivo<\/jats:italic> results and theoretical considerations the potential sensitivity for using nonelevated homocarnosine to measure pH is similar to that of <jats:italic>P<\/jats:italic><jats:sub>i<\/jats:sub> under physiological conditions.<\/jats:p>","DOI":"10.1002\/mrm.1910380611","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T10:35:08Z","timestamp":1173782108000},"page":"924-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Homocarnosine and the measurement of neuronal pH in patients with epilepsy"],"prefix":"10.1002","volume":"38","author":[{"given":"Douglas L.","family":"Rothman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Behar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Prichard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ognen A. 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